Medullary thyroid cancer (MTC) is a distinct C-cell tumor of the thyroid. We review the oncogenesis and management of both sporadic tumors and those tumors arising as part of specific inherited syndromes. The RET proto-oncogene plays a role in the development of inherited forms of MTC and has become important in the clinical management of patients and their families. The recognition of the high...

Renal medullary carcinoma (RMC) is a rare, highly aggressive tumor recognized as an independent pathological entity. African-descent adolescents and young adults with sickle cell hemoglobinopathy are the most affected groups. This rare subtype of renal cell carcinoma has its own morphogenetic and pathological characteristics. The major clinical manifestations include gross hematuria, abdominal ...

Introduction/Objective. Alcohol abuse influence on developing thyroid cancer is controversial. While some studies consider it a protective factor, others deny any impact cancer. The objective of the paper was to establish possible link between alcohol and certain types cancers. Methods. retrospective study included 502 patients with control group 600 benign forms diseases (e.g. nodular, multino...

A case of 64-year-old female patient with early stage gastric medullary carcinoma has been presented, along with a review of the literature.

Background. To evaluate the elevation rate of serum markers calcitonin (CT) and procalcitonin (ProCT) in patients with non-medullary benign and malignant thyroid nodules. Methods. Before surgery CT and ProCT were measured in sera from 168 patients with histologically proven benign thyroid nodules (n=107) and non-medullary thyroid carcinomas (n=61). Sera from 112 apparently healthy blood donors ...

Parathyroid carcinoma is a very rare malignancy. It has been associated with hyperparathyroidism-jaw tumour syndrome, familial isolated primary hyperparathyroidism, and multiple endocrine neoplasia type 1 (MEN-1) and 2A (MEN-2A) syndromes. We report a 54-year-old man with a MEN-2A which presents with a nonfunctional metastatic parathyroid carcinoma and a pheochromocytoma in the absence of medul...

Metastatic disease to the breast accounts for less than 1% of all breast carcinoma. Here we describe an unusual case of a 34-year-old black female with history of sickle cell trait who presented to her gynecologist with bilateral palpable breast masses. Based on initial workup including pathology results from biopsies of both breast masses, she was diagnosed with bilateral breast cancer. Howeve...

OBJECTIVE To study the clinical parameters and treatment outcome of medullary thyroid carcinoma in Hong Kong Chinese patients. DESIGN Retrospective study. SETTING Regional oncology unit, Hong Kong. PATIENTS Patients with medullary thyroid carcinoma who were identified among 1656 patients with thyroid malignancies seen in a single institute in Hong Kong from January 1960 to June 2003. MA...