Melanocytes are highly specialised dendritic cells that transfer melanin to keratinocytes in subcellular lysosome-like organelles called melanosomes, where is synthesised and stored. Melanin a complex pigment provides colour photoprotection the skin, hair, eyes of mammals. The regulation melanogenesis includes various mechanisms factors including genetic, environmental, endocrine factors. Knowl...

Actinic lichen planus is a clinical variant of lichen planus, involving mainly sun-exposed areas and manifested as annular lesions with a pigmented center surrounded by a hypopigmented zone. A rare presentation of actinic lichen planus mimics melasma but have distinctive histopathologic picture in favour of actinic lichen planus. Herein, we report a 14-year-old boy who presented with a me...

Abbreviations: UV-R: UV Radiation; SCF: Stem Cell Factors; FGF2: Fibroblast Growth Factor; PAH: Phenylalanine Hydroxylase; TH1: Tyrosinase Hydroxylase 1; TRP-2: DOPA-Chrome Tautomerase; TRP-1: DHICA Oxidase; DHI: 5,6-Dihydroxyindole; DHICA: 5;6-Dihydroxyindole-2-Carboxylic Acid; Indole-5;6-Quinone I-Q; I-QCA: Indole-5,6-Quinone Carboxylic Acid; MSH: MelanocyteStimulating Hormone; TYR: Tyrosinas...

O melasma é uma hipercromia adquirida, caracterizada por manchas assimétricas, de cor castanha, localizadas preferencialmente em regiões fotoexpostas, como rosto, e áreas pescoço, colo antebraços. distúrbio afeta homens mulheres fototipos intermediários, com idade média 30 a 55 anos, embora atinja principalmente mulheres. Sua etiologia ainda não se encontra totalmente esclarecida, mas sabe-se, ...

Background: Melasma is a common acquired pigmentary disorder that aesthetically displeasing. Kligman’s and Modified formula using topical steroids, hydroquinone retinoids, various other depigmenting agents being widely used all over for melasma with varying results. Chemical peeling newly added to the therapeutic armamentarium showing encouraging results worldwide in patients melasma. However, ...