BACKGROUND Advanced liver cirrhosis is associated with systemic hemodynamic derangement leading to the development of severe complications associated with increased mortality. Copeptin is a stable cleavage product of the precursor of arginine vasopressin, a key-regulator in hemodynamic homeostasis. Copeptin is currently considered a reliable prognostic marker in a wide variety of diseases other...

background the evidence saying that the rate of systemic inflammatory response syndrome (sirs) is high in patients with advanced cirrhosis and portal hypertension, this could have negative outcome on patients prognosis. methods this prospective study included 109 cirrhotic patients who were admitted to imam khomeini hospital, affiliated with orumieh university of medical sciences, during 2011-2...

BACKGROUND prognostic scores have been validated in cirrhotic patients admitted to general Intensive Care Units. No assessment of these scores was performed in cirrhotics admitted to specialized Gastroenterology Intensive Care Units (GICUs). AIM to assess the prognostic accuracy of Acute Physiology and Chronic Health Evaluation (APACHE) II, Simplified Acute Physiology Score (SAPS) II, Sequent...

The liver organ allocation policy of the United Network for Organ Sharing (UNOS) is based on the model for end-stage liver disease (MELD). The policy provides additional priority for candidates with hepatocellular carcinoma (HCC) who are awaiting deceased donor liver transplantation (DDLT). However, this priority was reduced on February 27, 2003 to a MELD of 20 for stage T1 and of 24 for stage ...

BACKGROUND & AIMS Prognostic tests are critical in the management of patients with cirrhosis and ascites. Biological tests or scores perform poorly in that situation. Mid-infrared fibre evanescent wave spectroscopy (MIR-FEWS) which allows for global serum metabolic profiling may provide more relevant information by measuring a wider range of metabolic parameters in serum. Here we present the ac...

INTRODUCTION The model for end-stage liver disease (MELD) score is used in many countries to prioritize organ allocation for the majority of patients who require orthotopic liver transplantation. This score is calculated based on the following laboratory parameters: creatinine, bilirubin and the international normalized ratio (INR). Consequently, high measurement accuracy is essential for equit...

For decompensated liver cirrhosis and hepatocellular carcinoma, liver transplantation provides these patients the only curative treatment option with better long-term results. The Model for End-stage Liver Disease (MELD) system is a good tool to predict short-term mortality among these patients and has also been applied to allocate liver grafts to patients on waiting lists in several countries....

Background: The clinical significance of serum sodium levels and its association with a higher rate complications in cirrhosis is debatable. This study was done to the chronic liver disease (CLD) patients establish severity such patients.Methods: In this cross-sectional study, we included adult diagnosed CLD assessed their electrolytes. using Child Pugh score (CPS) model for end stage (MELD). T...

The physiological implications of end-stage liver disease (ESLD) are so pervasive that measuring the severity of the disease is challenging and imperfect. Although the Model for End-Stage Liver Disease (MELD) score is convenient and reliable, clinicians appreciate the broad range of disease severity among patients with any given MELD score. Within this context, most MELD-based allocation system...

Variceal bleeding as a complication of portal hypertension carries significant morbidity and mortality, despite improvement in the therapeutic approaches available [1,2]. Risk stratification for mortality and early re-bleeding is important for the delivery of effective therapy in a timely manner [1]. Several risk factors for acute variceal bleeding (AVB) have been identified as poor prognostic ...