BACKGROUND Patients with type 2 diabetes mellitus are at increased risk for the development of atherosclerosis. A pivotal event in the development of atherosclerosis is macrophage foam cell formation. The ATP-binding cassette (ABC) transporters ABCA1 and ABCG1 regulate macrophage cholesterol efflux and hence play a vital role in macrophage foam cell formation. We have previously found that chro...

BACKGROUND Diabetes mellitus is a leading cause of major lower extremity amputation. OBJECTIVE To examine the influence of gender, level of amputation and diabetes mellitus status on being fit with a prosthetic limb following lower extremity amputation for peripheral arterial disease. STUDY DESIGN Retrospective analysis of the Scottish Physiotherapy Amputee Research Group dataset. RESULTS...

OBJECTIVE To investigate the prevalence of and risk factors for overweight and diabetes mellitus in long-stay psychiatric inpatients. METHOD Statistical analysis of data collected from medical, laboratory, and pharmacy files. RESULTS 80% of the 256 patients were suffering from schizophrenia or other psychotic disorders. The prevalence of diabetes mellitus was 15%. The prevalence of a distur...

In patients with type 1 (T1D) and type 2 diabetes mellitus (T2D), cardiovascular disease is the most common cause of death, 45% and 52%, respectively. In particular, diabetes mellitus is associated with microand macrovascular complications resulting in coronary heart disease and increased morbidity and mortality. Similarly, patients with diabetes mellitus are at high risk for peripheral arteria...

D iabetes mellitus is a common chronic disease that is characterized and defined by an elevated glucose level and that has grown in prevalence by 75% in the United States during a 20-year period ending in 2010. 1 The exact reason for this rising prevalence is not known with certainty; however, a large body of evidence implicates changes in weight, caloric consumption, reduced physical activity,...

BACKGROUND Platelets from patients with diabetes mellitus are hyperactive. Hyperactivated platelets may contribute to cardiovascular complications and inadequate responses to antiplatelet agents in the setting of diabetes mellitus. However, the underlying mechanism of hyperactivated platelets is not completely understood. METHODS We measured P2Y12 expression on platelets from patients with ty...

BACKGROUND AND PURPOSE Diabetes mellitus is an independent risk factor for lacunar strokes. Few data are available regarding patient features, infarct location, and recurrent vascular events for patients with diabetes mellitus with lacunar stroke. METHODS We compared features at study entry and prognosis during 3.6 years of follow-up of patients with diabetes mellitus versus patients without ...

Marquardt and Loriaux (I974) describe a kinship of two siblings with the combination of diabetes mellitus, diabetes insipidus, and optic atrophy in which there was additional evidence of renal tract dilatation, amino-aciduria, and neurosensory hearing deficit. These authors cite 41 cases of optic atrophy and diabetes mellitus reported since an association of these conditions was first described...

BACKGROUND The comparative long-term risk of non-traumatic lower extremity amputation (LEA) in black and white Americans, 2 groups with strikingly different rates of diabetes mellitus, is not known. OBJECTIVE To examine the 20-year incidence of LEA in relation to race and diabetes mellitus. METHODS The 14 407 subjects in the National Health and Nutrition Examination Survey Epidemiologic Fol...