cancer is one of the most fatal diseases in human beings which annually leads to death of 30000 individuals in iran. prevention, diagnosis and treatment of cancer is one of the major scientific challenges all around the world. it seems that increased incidence of several cancers such as colon and prostate and their mortality are connected with obesity. it is suggested that obesity and metabolic...

the oxidation of n-pentanol by tetramethylammonium fluorochromate in acidic solution wasstudied using spectrophotometric technique. the reaction was arranged to be under pseudo firstorderconditions respect to the oxidant. a michaelis-menten type kinetic was observed respect tothe substrate. the reaction is catalyzed by hydrogen ions. dependences of the reaction rates ontemperature and different...

The molecular mechanism responsible for cell fate after mitotic slippage remains unclear. We investigated the different postmitotic effects of aneuploidy versus polyploidy using chemical inhibitors of centromere-associated protein-E (CENP-E) and kinesin family member 11 (KIF11, also known as Eg5). Aneuploidy caused substantial proteotoxic stress and DNA damage accompanied by p53-mediated postmi...

Cytoplasmic double-stranded DNA triggers cell death and secretion of the pro-inflammatory cytokine IL-1beta in macrophages. Recent reports now describe the mechanism underlying this observation. Upon sensing of DNA, the HIN-200 family member AIM2 triggers the assembly of the inflammasome, culminating in caspase-1 activation, IL-1beta maturation and pyroptotic cell death.

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− The results of exact time domain analysis of the switched-mode tuned Class E power amplifiers with a quarterwave transmission line are presented with analytical determination of the optimum load network parameters. Effects of the quarterwave transmission line and collector capacitance on the current and voltage waveforms are discussed and analyzed. The ideal collector voltage and current wave...

Yeast functional screening with a Sophora flavescens cDNA library was performed to identify the genes involved in the tolerant mechanism to the self-producing prenylated flavonoid sophoraflavanone G (SFG). One cDNA, which conferred SFG tolerance, encoded a regulatory particle triple-A ATPase 2 (SfRPT2), a member of the 26S proteasome subunit. The yeast transformant of SfRPT2 showed reduced SFG ...

We discuss how relationships can be employed to embody role models at the programming language level. We show that member interposition, a mechanism that we introduced for the specification and verification of object collaborations, is particularly helpful for the description of the role-dependent properties of an object.