We prepared pH-sensitive anionic liposomes composed solely of anionic bilayer membrane components that were designed to promote efficient release of entrapped agents in response to acidic pH. The pH-sensitive anionic liposomes showed high dispersion stability at neutral pH, but the fluidity of the bilayer membrane was enhanced in an acidic environment. These liposomes were rather simple and wer...

new biodegradable network polymers containing siloxane-linked polymeric prodrugs of 5-ammino-2-hydroxybenzoic acid (5-asa) in the main chain were prepared by ter polymerization of methacrylic acid (ma), 2-hydroxyethylmethacrylate (hema), and bis (trimethylsilyloxy) methylsilane (vbm) in the presence of some new cross-linking agents.the monomers and polymers were characterized by ft-ir and 1h-nm...

There is a compelling and growing need to accurately predict the impact of amino acid mutations on protein stability for problems in personalized medicine and other applications. Here the ability of 10 computational tools to accurately predict mutation-induced perturbation of folding stability (ΔΔG) for membrane proteins of known structure was assessed. All methods for predicting ΔΔG values per...

Sodium bicarbonate cotransporter 1 (NBC1) mediates 80% of bicarbonate reabsorption by the kidney, but the molecular determinants for activity, targeting, and cell membrane stability are poorly understood. We generated truncation mutants involving the entire NH(2) (DeltaN424) or the entire COOH (DeltaC92) terminus and examined the effects of these truncations on targeting, cell membrane stabilit...

The novel liquid-infused membranes have been shown to mitigate membrane biofouling. Here, the long-term stability of these tested and analyzed using bacterial growth curve models.

in this study the catalytic dehydrogenation of ethylbenzene to styrene was investigated in a simulated tubular sodalite membrane reactor. the high quality microporous sodalite membrane was synthesized by direct hydrothermal method and characterized by single gas permeation measurements. the performance of the prepared membrane showed high potential for application in a dehydrogenation membrane ...