Late infantile GM1 gangliosidosis is an extremely rare metabolic disorder with clinical features of seizure and progressive motor and mental retardation without facial dysmorphism or visceral organomegaly. We report the CT and MR imaging findings in one infant, which included abnormalities of the cerebral cortex, white matter, and deep nuclei.

Functional magnetic resonance imaging (fMRI) is a powerful technique for measuring brain activity associated with the performance of different mental tasks. We briefly describe this technique and the images it produces and review methods of analysis that have been applied to fMRI data. Throughout the paper, we illustrate various points on an fMRI dataset.

Fabiana Mesquita Carvalho1,2 and Nikolaus Kriegeskorte3 1Graduate Program in Psychobiology, NeuroImago Laboratory, Department of Physics and Mathematics, University of São Paulo, CEP 14040-901, Ribeirão Preto, Brazil, 2Department of Psychology, University of Glasgow, Glasgow G12 8QB, United Kingdom, and 3Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institut...

Functional magnetic resonance imaging (fMRI) studies have demonstrated a critical role for a cortical region in the right temporo-parietal junction (RTPJ) in "theory of mind" (ToM), or mental state reasoning. In other research, the RTPJ has been implicated in the deployment of attention to an unexpected stimulus. One hypothesis ("attention hypothesis") is that patterns of RTPJ activation in ToM...

feel for the melancholy Dane in Hamlet or the chill during a perusal of the Raven? Our brains have absorbed from our senses a printed sequence of letters and then converted them into vivid mental experiences and potent emotions. The Òblack boxÓ description of the brain, however, fails to pinpoint the speciÞc neural processes responsible for such mental actions. While philosophers have for centu...

OBJECTIVE AND IMPORTANCE Spontaneous intracranial hypotension is an increasingly recognized cause of postural headache. However, appropriate management of obtundation caused by intracranial hypotension is not well defined. CLINICAL PRESENTATION A 43-year-old man presented with postural headache followed by rapid decline in mental status. Imaging findings were consistent with the diagnosis of ...

N. C. Scantlebury, W. Gaetz, E. Widjaja, J. Rutka, E. Bouffet, C. Rockel, and D. Mabbott Program in Neuroscience and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada, Biomagnetic Imaging Laboratory, Children's Hospital of Philadelphia, Philadelphia, PA, The Hospital for Sick Children, Neurosurgery, The Hospital for Sick Children, Haemotology/Oncology, The Hospital for Sic...

The presence of accessory foramina and canals in the mandible is frequently overlooked in clinical procedures. It is important to note that these anatomical variations may only be pre-surgically detected on imaging exams, and such detection may directly influence therapeutic success. We describe a previously unreported case of accessory mental foramen located in the lingual cortical bone of the...

The superior temporal sulcus (STS) is implicated in a variety of social processes, ranging from language perception to simulating the mental processes of others (theory of mind). In a new study, Deen and colleagues use functional magnetic resonance imaging (fMRI) to show a regular anterior-posterior organization in the STS for different social tasks.