This paper 1 deals with presuppositional effects by the temporal discourse markers after and before within a multi-sentence discourse. By presenting data wrt. implicitly expressed causal relations, the proposal by Lascarides and Oberlander (1993) is criticised and a formalisation of the discourse usage of the two temporal connectives is given by extending van der Sandt’s (1992) approach to pres...

The purpose of the study reported in this paper is to investigate how local focusing structure, analysed in terms of Centering Theory (Grosz, Joshi & Weinstein, 1995), and global d iscourse structure, analysed in terms of discourse segments and discourse segment purposes (Grosz & Sidner, 1986), interact. Swedish dialogue was analysed according to Centering Theory and Grosz and Sidners (1986) di...

OBJECTIVES To evaluate the replication capacity and phenotypic susceptibility to dolutegravir and raltegravir of wild-type and raltegravir-resistant HIV-1 strains in several cellular systems. METHODS The antiviral activities of dolutegravir and raltegravir were evaluated in human primary monocyte-derived macrophages (MDMs), peripheral blood mononuclear cells (PBMCs) and C8166 T lymphocytic ce...

Lectin-like oxidized LDL receptor-1 (LOX-1) is a newly identified receptor for oxidized LDL that is expressed by vascular cells. LOX-1 is upregulated in aortas of diabetic rats and thus may contribute to the pathogenesis of human diabetic atherosclerosis. In this study, we examined the regulation of human monocyte-derived macrophage (MDM) LOX-1 expression by high glucose and the role of LOX-1 i...

Glioblastoma cells produce and release high amounts of glutamate into the extracellular milieu and subsequently can trigger seizure in patients. Tumor-associated microglia/macrophages (TAMs), consisting of both parenchymal microglia and monocytes-derived macrophages (MDMs) recruited from the blood, are known to populate up to 1/3 of the glioblastoma tumor environment and exhibit an alternative,...