Infrared multiple-photon dissociation spectroscopy reveals the nature of nitrous oxide binding to metal clusters.

PAS and related GAF are ubiquitous highly versatile sensing domains that associate a range of signaling effectors. Each year, new bacterial characterized but genomes analysis suggests this list is far from complete. This review aims to synthesize the current state knowledge on structure activity metal-binding PAS/GAF domain proteins. can bind disparate metal cofactors with very precise coordina...

Multifunctional metal chelators that can modulate the amyloid β (Aβ) peptide aggregation and its interaction with metal ions such as copper and zinc hold considerable promise as therapeutic agents for Alzheimer's disease (AD). However, specific rather than systemic metal chelation by these compounds is needed in order to limit any side effects. Reported herein are two novel small bifunctional c...

Metal ions play a functional role in numerous biochemical processes and cellular pathways. Indeed, about 40% of all enzymes of known 3D structure require a metal ion to be able to perform catalysis. The interactions of the metals with the macromolecular framework determine their chemical properties and reactivity. The relevant interactions involve both the coordination sphere of the metal ion a...