Two cases of renal cell carcinoma, both of which underwent extensive spontaneous regression, are reported. The first occurred in a 56 year old man, forming a well circumscribed renal cortical nodule which contained only very occasional foci of viable renal cell carcinoma with areas of hyalinisation and calcification, and with metaplastic ossification. The second lesion was removed from an 82 ye...

Nephrolithiasis is a common entity encountered in general population. Nephrolithiasis refers to formation and impaction of stones in renal pelvis and calyces. Long standing stones cause irritation, chronic inflammation and may cause ‘metaplasia’ of lining epithelium. The metaplasia is commonly of squamous and glandular epithelium. Metaplastic epithelium may further undergo dysplasia and result ...

Squamous cell carcinoma in the lung originates from bronchial epithelial cells that acquire increasingly abnormal phenotypes. Currently, no known biomarkers are clinically efficient for the early detection of premalignant lesions and lung cancer. We sought to identify secretedmolecules produced from squamous bronchial epithelial cells cultured with organotypic culture methods. We analyzed prote...

BACKGROUND In the current study the authors describe the clinicopathologic characteristics of a low grade variant of spindle cell metaplastic tumors of the breast. Previously these tumors have been considered within a larger group recognized as metaplastic carcinoma, including cases with higher grade features. METHODS Breast tumors comprised predominantly of low grade spindle cells, with spar...

Squamous cell carcinoma in the lung originates from bronchial epithelial cells that acquire increasingly abnormal phenotypes. Currently, no known biomarkers are clinically efficient for the early detection of premalignant lesions and lung cancer. We sought to identify secreted molecules produced from squamous bronchial epithelial cells cultured with organotypic culture methods. We analyzed prot...

SOX9, an important factor for testis determination and chondrogenesis, was previously detected in the nucleus of testicular sertoli cells and chondrocytes but was found in only a subset of ovarian sertoli cell tumors, carcinoid tumors, and endometrioid carcinomas, and occasionally only in the cytoplasm of those cells. SOX9 has also been detected in metaplastic carcinomas of the breast exhibitin...