although splenic metastasis is fairly common in disseminated cancer, solitary splenic metastasis in the absence of diffuse dissemination is rare. we report a case of 44 year-old man who developed isolated splenic metastasis of colon cancer. the patient had undergone right sided hemicolectomy for colon cancer in 1988. in 2001, he underwent reoperation because of local recurrence of tumor in the ...

BACKGROUND IL-1α and IL-6 are associated with the prognosis of a wide range of cancers, but their value in cervical cancer remains controversial. The aim of this study was to investigate the expression of IL-1α and IL-6 in cervical cancer and their significance in clinical prognosis. MATERIAL AND METHODS The expression of IL-1α and IL-6 in 105 formalin-fixed, paraffin-embedded cervical cancer t...

background and aim: carcinoma of the uterine cervix is a significant cause of mortality because of malignancy in women. radiotherapy is a major treatment modality for invasive cervical cancer with good treatment outcome in early-stage patients. however, substantial treatment failures still occur in the advanced-stage patients. in this case report a long term follow up of a 58 years old woman wi...

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statement of the problem: the head and neck region is an uncommon site for metastatic involvement, but it can be the first and only symptom of primary cancer. the incidence of these tumors and their primary origins are limited in iranian patients. purpose: therefore, this retrospective study aimed to investigate the frequency and the common related clinical manifestations, as well as, the most ...

Cervical cancer is one of the most common cancers in Indonesia. It can be treated with molecular therapies targeting Matrix metallopeptidase 9 (MMP-9) and Glucose transporter (GLUT-1), which are enzymes that involved tumour cell invasion, metastasis angiogenesis. Zanthoxylum acanthopodium (andaliman) an Indonesian herb anti-cancer properties. This study aimed to investigate histological changes...

Objectives: Lymph node dissection (LND) in gynecological malignancies has always been a cornerstone the diagnosis of metastasis, it is also considered an important prognostic factor, and reliable guide to management strategies. However, its incidence complications, namely lymphedema, vascular injuries other lesions, led reconsideration efficacy comparison role systematic vs. sentinel lymph (SLN...

Patients with cervical cancer diagnosed with a para-aortic lymph node (PALN) metastasis by computed tomography (CT) scan were analyzed to identify associated prognostic factors. A total of 55 patients were reviewed, and 27 of these patients underwent extended-field radiotherapy (EFRT). The median PALN dose in patients receiving EFRT was 45 Gy (range, 27-57.6 Gy). Of the 55 patients, 28 underwen...

Our recent studies of microRNA (miRNA) expression signatures indicated that microRNA-29a (miR-29a) was significantly downregulated in several types of human cancers, suggesting that miR-29a may be a putative tumor-suppressive miRNA in human cancers. The aim of this study was to investigate the functional significance of miR-29a in cervical squamous cell carcinoma (SCC) and to identify novel miR...