نتایج جستجو برای: metastatic cancer
تعداد نتایج: 945594 فیلتر نتایج به سال:
Metastases are the main cause of cancer deaths, but the mechanisms underlying metastatic progression remain poorly understood. We isolated pure populations of cancer cells from primary tumors and metastases from a genetically engineered mouse model of human small cell lung cancer (SCLC) to investigate the mechanisms that drive the metastatic spread of this lethal cancer. Genome-wide characteriz...
PURPOSE Genome-wide association studies (GWAS) have identified multiple novel prostate cancer predisposition loci. Whether these common genetic variants are associated with incident metastatic prostate cancer or with recurrence after surgical treatment for clinically localized prostate cancer is uncertain. EXPERIMENTAL DESIGN Twelve single nucleotide polymorphisms (SNPs) were selected for stu...
Metastases from primary tumors are responsible for most cancer deaths. It has been shown that circulating tumor cells (CTCs) can be detected in the peripheral blood of patients with a variety of metastatic cancers and that the presence of these cells is associated with poor clinical outcomes. Characterization of CTCs in metastatic cancer patients could provide additional information to augment ...
background: chemokine receptors have been shown to play an important role in the development and metastatic spread of various malignancies. in this study, the gene expression profile of some key chemokine receptors involved in metastasis has been investigated in esophageal and breast cancer cell lines. methods: in a descriptive study, gene expression profile of ccr1, ccr6, ccr7, ccr9, cxcr1, ...
BACKGROUND Endometrial cancer is the most common gynecologic malignancy. The majority of patients have disease confined to the uterus and have an excellent overall prognosis. However, subgroups of patients have advanced primary disease or recurrences following primary treatment. METHODS The management of metastatic disease is variable, depending on factors such as comorbidities, tumor grade, ...
Cancer stem cells are implicated in tumor progression, metastasis, and recurrence, although the exact mechanisms remain poorly understood. Here, we show that the expression of cellular prion protein (PrPc, PRNP) is positively correlated with an increased risk of metastasis in colorectal cancer. PrPc defines a subpopulation of CD44-positive cancer stem cells that contributes to metastatic capaci...
Despite advances in cancer therapy, treating cancer after it has metastasized remains an unmet clinical challenge. In this study we demonstrate that 100 nm liposomes target triple-negative murine breast-cancer metastases post intravenous administration. Metastatic breast cancer was induced in BALB/c mice either experimentally, by a tail vein injection of 4T1 cells, or spontaneously, after impla...
Cancer is a pathology characterized by loss or perturbation of number typical features normal cell behaviour. Indeed, the acquisition an inappropriate migratory and invasive phenotype has been reported to be one hallmarks cancer. The cytoskeleton complex dynamic network highly ordered interlinking filaments playing key role in control fundamental cellular processes, like shape maintenance, moti...
Introduction: Cutaneous metastasis is a rare presentation of choriocarcinoma and as it is associated with advanced disease, it has poor prognostic sign. To the best of our knowledge about 11 cases of cutaneous metastatic choriocarcinoma were reported in the literature. Case Report: A 47-yr –old female complaining of cutaneous lesion with pruritis. She had history of choriocarcinoma followin...
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