Metformin in its protonated form as metformin hydrochloride is used worldwide an advanced antidiabetic drug for type 2 diabetes. Hyperinsulinemia and insulin resistance of cells are the main causes this disease. For patients with diabetes, (MET) works by improving cell sensitivity to insulin.
 It has been shown that methyl orange (MO) forms ionic associate can be isolated solid suitable cr...

This research approaches knowledge gaps related to the pickling process dynamic modelling (the lack of predictability and simplicity existing models) answers practical need for a software tool facilitate optimum operation (by delivering estimations corrosion inhibitor addition, bath lifetime, rate evolution, material mass loss). A decision-making tool, PickT, has been developed verified with he...

buprenorphine is a partial mu agonist and kappa antagonist which is used for the treatment of pain and opioid addiction. a mixture of buprenorphine hydrochloride and naloxone hydrochloride has been approved for the treatment of opioid dependence.in this study a third order derivative spectrophotometric method based on zero-crossing technique has been used for the simultaneous determination of b...

In this work, the potential of peach pit biosorption in removal drug metformin hydrochloride from water is evaluated. Experiments are carried out a closed batch system to evaluate effect solution pH (2–10), temperature (25, 35 and 45 °C), stirring (100, 150 200 rpm) chemical treatments. During study, biosorbent characterization, kinetic tests, equilibrium tests thermodynamic parameter calculati...

metformin has recently been introduced as an anti-cancer agent. in this study, we evaluated the effect of metformin and metformin/cisplatin on human gastric mkn-45 cell line. when we used metformin alone, it could inhibit proliferation and induce apoptosis, but it diminish anti-proliferative effects of cisplatin when they are used in combination. further, we checked mrna levels of survivin, mto...

The main objective of this study was to prepare sustained release metformin hydrochloride microcapsules by the Wurster fluidized bed and to obtain the optimized coating process and formulation. Fine microcapsules without agglomeration were obtained in a continuous coating process with the atomization air pressure of 0.2Mpa and an appropriate coating speed temperature. With other design variable...

In this paper we are presenting development and validation of an improved method for the simultaneous estimation of metformin hydrochloride (MET) and pioglitazone (PIO) using high-performance liquid chromatography (HPLC). A Phenomenex, Onyx monolithic C18 column (150x4.6mm) was used with a mobile phase containing a mixture of 25 mM sodium dihydrogen phosphate (PH 3.65 with orthophosphoric acid)...

A simple reversed-phase high-performance liquid chromatography method was developed and validated for simultaneous determination of Metformin hydrochloride (MET) and Glimepiride (GLM) in combination and estimation of their principal degradation products. The separation was achieved using JASCO Finepak SIL (250 mm × 4.6 mm i.d. 5 μm) at ambient temperature. The optimized mobile phase composed of...

OBJECTIVE The aim of this paper was to show that easily interpretable maps of local and national prescribing data, available from open sources, can be used to demonstrate meaningful variations in prescribing performance. DESIGN The prescription dispensing data from the National Health Service (NHS) Information Centre for the medications metformin hydrochloride and methylphenidate were compare...

An attempt was made to sustain the release of metformin HCl as well as to mask the bitter taste by complexation technique using strong cation-exchange resins, indion 244 and indion 264. The drug loading onto ion-exchange resin was optimized for mixing time, activation, effect of pH, mode of mixing, ratio of drug:resin and temperature. The resinate was evaluated for micromeritic properties, tast...