Methods We evaluated HIV-infected IDUs attending an inner city clinic in Vancouver who were receiving RGV-based HAART and methadone within a directly observed therapy program. Follow-up was according to clinical standards, with changes in methadone dose being made as required to achieve clinical stabilization within the first month of HAART. The change in methadone dosing associated with the in...

BACKGROUND Federal initiatives aim to increase office-based treatment of opioid dependence, but, to our knowledge, factors associated with willingness to deliver this care have not been defined. The objective of this study was to describe clinics' willingness to provide methadone hydrochloride or buprenorphine hydrochloride for opioid dependence. METHODS The design of the study was a survey c...

The pharmacokinetics of methadone varies greatly from person to person; so, after the administration of the same dose, considerably different concentrations are obtained in different subjects, and the pharmacological effect may be too small in some patients, too strong and prolonged in others. Methadone is mostly metabolised in the liver; the main step consists in the N-demethylation by CYP3A4 ...

− Methadone is a safe and effective long-acting opioid analgesic that is useful in managing chronic pain. − Although it has unique pharmacokinetic and pharmacodynamic properties, the general principles of dosing methadone are similar to those of other opioids. − In general, as with other opioids, methadone should be used as one aspect of a comprehensive pain management plan, as agreed upon by t...

normal 0 false false false en-us x-none fa microsoftinternetexplorer4 background : methadone is a synthetic opioid, used in treatment of chronic pains. the current study was carried out to evaluate the qtc interval in iranian causalities (janbazan) of iran-iraq war receiving maintenance methadone treatment. methods : in 2010, one hundred war causalities in isfahan who chronically take daily dos...

We report a case of high-dose methadone prescribed to a heroin addict for pain control. The patient was prescribed methadone during convalescence from surgery and subsequently for maintenance treatment. Dosing was started at 360 mg of methadone per day and reduced over 12 days to an 80 mg/day maintenance dose. Although the patient was drowsy on the initial dose, his recovery was uneventful. How...

background: in iran, methadone has been used for methadone maintenance treatment (mmt) as well as analgesic treatment in pain clinics. recently, there are some reports regarding accidental and intentional methadone poisonings and deaths. the aim of this study was to evaluate the trend of methadone poisonings and deaths during a 10-year period in tehran, iran. methods: this was a retrospective c...

INTRODUCTION The synthetic opioid methadone is a promising analgesic for the management of chronic neuropathic pain. Methadone therapy is increasing as its advantages are being realized over other opioids. Methadone's lack of known active metabolites, high oral bioavailability, low cost, and its additional receptor activity as an antagonist of N-methyl-D-aspartate receptors make it an attractiv...

Background: Interindividual variability and drug interaction studies suggest that blood–brain barrier drug transporters mediate human methadone brain biodistribution. In vitro and animal studies suggest that methadone is a substrate for the efflux transporter P-glycoprotein, and that P-glycoprotein–mediated transport influences brain access and pharmacologic effect. This investigation tested wh...

DESCRIPTION An independent panel developed cardiac safety recommendations for physicians prescribing methadone. METHODS Expert panel members reviewed and discussed the following sources regarding methadone: pertinent English-language literature identified from MEDLINE and EMBASE searches (1966 to June 2008), national substance abuse guidelines from the United States and other countries, infor...