A juvenile male mixed breed dog was presented for lethargy, exercise intolerance, and aggression when touched on the head. Cyanosis, tachycardia, and tachypnea were observed and persisted during oxygen supplementation. Arterial blood gas analysis by co-oximetry identified an increased methemoglobin concentration (27%; normal, <2%) with normal arterial oxygen tension. The methemoglobinemia and a...

Previous studies have concluded that polycythemia decreases oxygen delivery primarily because of a large fall in cardiac output associated with a rise in systemic vascular resistance that has been attributed to increased blood viscosity. However, because other studies have shown that polycythemia may not reduce oxygen delivery, an alternative hypothesis is that cardiac output falls in response ...

=> 7' 7 ,72 Recent studies of chronic hypercapnia in guinea pigs and rats demonstrated a biphasic shift in the blood oxygen dissociation curve, a diminution of heme-heme interaction and a significant decrease in the oxygen capacity of blood which was not due to decreased hemoglobin content. The latter finding suggested production of non-functional hemoglobin during hypercapnia. We measured the ...

In reviewing the article “Methemoglobinemia: Sudden Dyspnea and Oxygen Desaturation After Esophagoduodenoscopy,” in the August 2004 issue of RESPIRATORY CARE,1 I found the article suggested that, during the esophagoduodenoscopy procedure the patient’s blood oxygen saturation (measured via pulse oximetry) began to drop rapidly, and a saturation of 54% registered on the pulse oximeter while the p...

Electrophoretic and fingerprinting studies in a patient with congenital hemolytic anemia revealed the presence of the unstable hemoglobin K#{246}ln(f398 vat-suet). Examination of parents and siblings gave normal results. Extensive blood group and isozyme studies were consistent with the thesis that Hb K#{246}lndisease in the propositus was the result of a fresh mutation in one of his parent’s g...

In the course of a series of investigations on the physical chemistry of hemoglobin now being carried on in the Laboratory of Physical Chemistry of the Harvard Medical School, Dr. E. J. Cohn and Dr. R. M. Ferry discovered certain abnormalities in the behavior of a hydrogen electrode immersed in solutions of hemoglobin and oxyhemoglobin. On studying the matter further they found that any inert e...