All atom molecular dynamics simulations with explicit water were done to study the interaction between two parallel double-stranded DNA molecules in the presence of the multivalent counterions putrescine (2+), spermidine (3+), spermine (4+) and cobalt hexamine (3+). The inter-DNA interaction potential is obtained with the umbrella sampling technique. The attractive force is rationalized in term...

Hydro-mechanical transmission (HMT) based hybrid hydraulic vehicle architecture is potentially more efficient than other architectures because: 1) it uses the efficient mechanical transmission for partial power transfer, 2) it allows the engine to operate at its most efficient point. The input coupled power split hybrid vehicle being developed is one such example. The increase in degrees of fre...

Divalent metal (Mn, Co, Ni) complexes of the ligand hexamethylenetetramine (HMTA, C6H12N4) with sulfate, nitrate and fluoroborate as counter ions have been synthesized in ethanolic media. Whereas the complexes with BF4 and NO3 as counter ions have two molecules of hexamethylenetetramine, those with SO4 2as counter ion contain just one molecule of hexamethylenetetramine. The complexes have been ...

The photoreactions of HMT [4'-(hydroxymethyl)-4,5',8-trimethylpsoralen] monoadducts in double-stranded DNA have been studied with complementary oligonucleotides. The HMT was first attached to the thymidine residue in the oligonucleotide 5'-GAAGCTACGAGC-3' as either a furan-side monoadduct or a pyrone-side monoadduct. The HMT-monoadducted oligonucleotide was then hybridized to the complementary ...

Figure 2. Gadolinium-enhanced MRI sequence showing ring-enhancing lesions within the basal ganglia (arrow). Figure 1. Fluid-attenuated inversion recovery MRI sequence demonstrating vasogenic and cytotoxic edema in the bilateral basal ganglia (arrows). Diagnosis: Isolated cerebral mucormycosis of the basal ganglia. Brain biopsy tissue was obtained by stereotactic biopsy of the right basal gangli...

drug prescription errors are a common cause of adverse incidents and may lead to adverse outcomes, sometimes in subtle ways, being compounded by circumstances or further errors. therefore, it is important that veterinarians issue the correct drug at the correct dose. using two or more prescribed drugs may lead to drug interactions. some drug interactions are very harmful and may have potential ...

OBJECTIVES Nitrofurantoin has been used for the prevention of urinary tract infection (UTI) for over 60 years. We conducted a systematic review and meta-analysis to assess its efficacy and safety in the prophylaxis of UTI. METHODS We performed a systematic review of all controlled trials in humans assessing nitrofurantoin for UTI prophylaxis published from 1946 to 2015. We further reviewed po...

An 80-year old man was admitted suffering from a painful, enlarged right testicle for approximately one month. His medical history revealed a transurethral resection of the prostate for benign hyperplasia seven years before. The resection, performed in another hospital, was complicated by recurrent strictures of the urethra and several episodes of lower urinary tract infection. Internal urethro...

Drug prescription errors are a common cause of adverse incidents and may lead to adverse outcomes, sometimes in subtle ways, being compounded by circumstances or further errors. Therefore, it is important that veterinarians issue the correct drug at the correct dose. Using two or more prescribed drugs may lead to drug interactions. Some drug interactions are very harmful and may have potential ...

This work deals with the statistical restoration of a hidden signal using Pairwise Markov Trees (PMT). PMT have been introduced recently in the case of a discrete hidden signal. We first show that PMT can perform better than the classical Hidden Markov Trees (HMT) when applied to unsupervised image segmentation. We next consider a PMT in a linear Gaussian model with continuous hidden data, and ...