The intracellular mechanism by which interferon-gamma induces the expression of class II major histocompatibility complex (MHC) antigen in nonlymphoid cells is not clear. The effect of recombinant rat interferon-gamma (IFN-gamma), and cycloheximide on the expression of class II MHC gene was studied using the techniques of immunocytochemical staining and northern blot analysis. IFN-gamma induced...

Abstract MHC-I molecules are involved in the predisposition to several immune diseases. Reactive arthritis (ReA) is strongly linked with Chlamydia trachomatisinfection and HLA-B*27. However, how can contribute pathology not well understood. Chlamydiais an intracellular pathogen one of its main pathogenic factors CPAF. This enzyme secreted cytosol host during infection there no data regarding gl...

10.1152/ japplphysiol.00832.2001.-To examine the effects of gene inactivation on the plasticity of skeletal muscle, mice null for a specific myosin heavy chain (MHC) isoform were subjected to a voluntary wheel-running paradigm. Despite reduced running performance compared with nontransgenic C57BL/6 mice (NTG), both MHC IIb and MHC IId/x null animals exhibited increased muscle fiber size and mus...

During maturation, dendritic cells (DCs) regulate their capacity to process and present major histocompatibility complex (MHC) II-restricted antigens. Here we show that presentation of exogenous antigens by MHC I is also subject to developmental control, but in a fashion strikingly distinct from MHC II. Immature mouse bone marrow-derived DCs internalize soluble ovalbumin and sequester the antig...

The purpose of this study was to examine the role of myosin heavy chain (MHC) in determining loaded shortening velocities and power output in cardiac myocytes. Cardiac myocytes were obtained from euthyroid rats that expressed alpha-MHC or from thyroidectomized rats that expressed beta-MHC. Skinned myocytes were attached to a force transducer and a position motor, and isotonic shortening velocit...

AIM To survey the attitudes of a population of Australian men to potential use of male hormonal contraception (MHC). DESIGN Survey of male partners of women who had recently given birth. Men were approached while visiting their female partners on the ward. PARTICIPANTS 118 out of 148 Australian-born English-speaking men who were approached. SETTING Postnatal ward of Monash Medical Centre ...

The ability of TAP1-/-, beta2m-/-, and TAP1/beta2m-/- mice to mount rejection responses against allogeneic, syngeneic, and MHC class I-deficient tumor grafts was examined. The results demonstrate a potent ability of TAP1-/- and beta2m-/- as well as TAP1/beta2m-/- mice to reject allogeneic tumors. In contrast to published data, rejection of syngeneic MHC class I-expressing tumors was also observ...

Loss or downregulation of MHC class I molecules on tumour cells is a common mechanism by which tumours can escape from T-cell mediated immune responses. In this study we have investigated the immunologic crossreactivity between murine tumour cell lines expressing human papilloma virus (HPV) 16-derived E6/E7 oncoproteins with distinct surface expression of MHC class I molecules. The aims of this...

A person chooses a mate with advantageous genes through odor and facial symmetry. Dustin J. Penn and Wayne K. Potts discovered that mice are capable of smelling the potential mates’ major histocompatibility complex (MHC) through the scent of urine. Penn and Potts found that the mice preferred the scent of mates with a dissimilar MHC genotype to their own. Claus Wedekind investigated an odor med...