Background: The high saturated fatty acid content of beef has been linked to obesity and cardiovascular diseases. study investigated the impact black seed oil (BSO) on fat-altered hemato-biochemical pathophysiological alterations in albino mice. Methods: Twenty four Swiss Albino mice (Mus musculus) 25-28 days old were equally divided into three groups (n=8) namely A, B C. Mice group A was desig...

background: despite major progress in our general knowledge related to the application of adult stem cells, finding alternative sources for bone marrow mesenchymal stem cells (mscs) has remained to be challenged. in this study successful isolation, multilineage differentiation, and proliferation potentials of sheep mscs derived from bone marrow, adipose tissue, and liver were widely investigate...

Oxidized, damaged and misfolded proteins accumulate during aging contribute to impaired cell function tissue homeodynamics. Damaged are degraded by cellular clearance mechanisms like the 20S proteasome. Aging relates low proteasome function, whereas long-lived species show high levels. However, contradictory results exist depending on or type it is unknown how functions in exceptionally old mic...

The specific interaction of glucocorticoids with fetal and adult rabbit tissues was studied in vitro. Specific cytoplasmic binding sites for [aH]dexamethasone were demonstrated in liver, thymus, kidney, lung, muscle, heart, small intestine, skin, brain, and placenta of the rabbit fetus as well as in liver, thymus, spleen, kidney, small intestine, and lung of the adult rabbit. In the rabbit fetu...

Background: Sepsis is a systemic inflammatory disease in response to the pathogens that leads to vital organ failures the failure of vital organs. Appropriate animal models should be developed to measure the effectiveness of therapeutic methods. Cecal Ligation and Puncture (CLP) is the most widely used methods of creating the sepsis model. Some variables interfere in the creation of the CLP mod...

background and aims: kombucha is an ancient food and healing source with asian origin. kombucha consists of a wide range of acids, including vitamin c, organic materials, enzymes, and b-group vitamins, which has provided it with immense value. this study was aimed to investigate the effects of kombucha tea consumption on hepatic udpgt enzyme in mice. methods: in this experimental study, 21 smal...

The aim of this study was to characterize the responses of individual tissues to high-fat feeding as a function of mass, fat composition, and transcript abundance. We examined a panel of eight tissues [5 white adipose tissues (WAT), brown adipose tissue (BAT), liver, muscle] obtained from DBA/2J mice on either a standard breeding diet (SBD) or a high-fat diet (HFD). HFD led to weight gain, decr...

SUMMARY Pregnant and nonpregnant mice received injections of 3-methylcholanthrene-' 4C by several routes and were killed after various intervals. Macroautoradiographs of whole-body sections were examined, and the radioactivity in several organs was measured. The distribution of the compound in various tissues and its clearance were elucidated from the data obtained. This carcinogen is metaboliz...

Metabolic syndrome (MS) is a widespread polyethiological clustering characterized by metabolic, hormonal disorders and clinical manifestations that significantly increase the risk of developing cardiovascular diseases, atherosclerosis, type II diabetes other pathological conditions. An important role in development MS assigned to intestinal microbiota. To develop new therapeutic agents for corr...