Deficiency of adenosine deiminase 2 (DADA2) syndrome is a recently described autosomal recessively inherited autoinflammatory disorder associated with missense mutations in CECR1 gene. Clinical manifestations include early onset stroke, livedoid vascular changes, and a vasculopathy mimicking classical polyarteritis nodosa (cPAN) characterized by microaneurysms and associated inflammatory findin...

Because the pathogenetic understanding of diabetic vascular complications remains fragmentary, and even the best available interventions may prove insufficient to arrest the progression of certain lesions, new avenuses of investigation should be pursued. One of these should be the early in vivo investigation of the cells that endure the pathological process (pericytes and endothelial and mesang...

We proposed a novel approach to automatic classification of Diabetic Retinopathy (DR) images and retrieval of clinically-relevant DR images from a database. Given a query image, our approach first classifies the image into one of the three categories: microaneurysm (MA), neovascularization (NV) and normal, and then it retrieves DR images that are clinically-relevant to the query image from an a...

Diabetic retinopathy prevention requires the screening of large numbers of patients, and examination of a huge amount of images, since diabetic patients typically have both their eyes examined at least once a year. To effectively manage all this information and the workload it produces, automatic techniques for analyzing the images are required. These techniques must be robust, sensitive and sp...

To cite: Amin OSM, Mahmood MM. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2017219300 DESCRIPTION A woman aged 71 years with hypertension developed sudden severe headache and right-sided weakness. The blood pressure was 210/135 mm Hg. She was drowsy. Examination revealed right-sided upper motor neuron facial weakness, hemiparesis, hemi-anaesthesia and extensor...

THE purpose of this report is to describe the presence of microaneurysms in the retinae of patients who died with leukaemia. Although this type of lesion is most frequently observed in association with diabetes mellitis, it has, during recent years, been described clinically and/or histologically in association with a diverse variety of apparently unrelated entities. In a few instances the lesi...

The bulk of spontaneous basal ganglia hemorrhages result from rupture of the small perforating intracerebral arteries and a clinical background of hypertension. Charcot and Bouc hard [1] noted that most microaneurysms occurred in hypertensive brains due to miliary microaneurysms involving branches of lenticu lostriate and thalamoperforating arteries. Such microaneurysms were subsequently demons...

PURPOSE Diabetic retinopathy (DR) is a major cause of blindness globally. Investigating the underlying mechanisms of DR would be aided by a suitable mouse model that developed key features seen in the human disease, and did so without carrying genetic modifications. This study was undertaken to produce such a model. METHODS Our panel of Collaborative Cross strains was screened for DR-like fea...

Vitamin D has been linked to various cardiovascular risk factors including indices of large-vessel disease. However, it remains unclear whether vitamin D is also associated with microvascular damage. In a community-dwelling population, we studied associations between vitamin D serum levels and retinal microvascular damage defined as retinopathy signs, narrower arterioles, and wider venules.From...

Takayasu arteritis is a large vessel systemic granulomatous vasculitis characterized by stenosis or obliteration of large and medium sized arteries. It commonly involves elastic arteries such as the aorta and its main branches. Renal artery involvement is rare and has not been reported in a child. We report a 12-year-old boy with Takayasu arteritis who developed severe hypertension, proteinuria...