Cimetidine is an odourless white to off-white powder, which is sparingly soluble in water. Each Magicul tablet contains 200 mg, 400 mg or 800 mg of cimetidine. The tablets also contain maize starch, povidone, microcrystalline cellulose, sodium starch glycollate (Type A), magnesium stearate, Opadry Green OY8830 (ARTG no. 1538) for 200 mg and 800 mg tablets, and Opadry White Y-1-7000 E171 (ARTG n...

Cellulose-binding domains (CBDs) bind specifically to cellulose, and form distinct domains of most cellulose degrading enzymes. The CBD-mediated binding of the enzyme has a fundamental role in the hydrolysis of the solid cellulose substrate. In this work we have investigated the reversibility and kinetics of the binding of the CBD from Trichoderma reesei cellobiohydrolase I on microcrystalline ...

Oligo(L-lactic acid) (OLLA) was synthesized by ring opening polymerization of L-lactides using stannous octoate (0.03 wt% lactide). While this served as the initiator, L-lactic acids were co-initiators at 140 °C for 10 h, wherein prepared hydrolytic degradation 100 1 h. The molecular weight or degree controlled with monomer/co-initiator ratio (mol/mol). α-cellulose and microcrystalline cellulos...

Powder characteristics are very important to consider in the tablet manufacturing process because they can affect of resulting tablets. This study aims determine microcrystalline cellulose powder isolated from soursop leaves. research method includes preparation leaves raw material, isolation α-cellulose using 17.5% NaOH solution with 3.5% nitric acid (containing 20 mg sodium nitrite), manufact...

Enzyme catalyzed conversion of plant biomass to sugars is an inherently inefficient process, and one of the major factors limiting economical biofuel production. This is due to the physical barrier presented by polymers in plant cell walls, including semi-crystalline cellulose, to soluble enzyme accessibility. In contrast to the enzymes currently used in industry, bacterial cellulosomes organiz...

The aim of this work is to describe and characterize a new spray-drying procedure for the production of nasal powders as an alternative to the conventional freeze-drying method. Cyanocobalamin was chosen as the active ingredient and loaded into five different nonsoluble vehicles with high water absorption ability. Then these hydrated particles were suspended in methylene chloride and spray-drie...

Edivoxetine (LY2216684 HCl), although a chemically stable drug substance, has shown the tendency to degrade in the presence of carbohydrates that are commonly used tablet excipients, especially at high excipient:drug ratios. The major degradation product has been identified as N-formyl edivoxetine. Experimental evidence including solution and solid-state investigations, is consistent with the N...