Submicron particles such as latex spheres and viruses can be manipulated and characterized using dielectrophoresis. By the use of appropriate microelectrode arrays, particles can be trapped or moved between regions of high or low electric fields. The magnitude and direction of the dielectrophoretic force on the particle depends on its dielectric properties, so that a heterogeneous mixture of pa...

Spatiotemporally coordinated activity of neural networks is crucial for brain functioning. To understand the basis of physiological information processing and pathological states, simultaneous multisite long-term recording is a prerequisite. In a multidisciplinary approach we developed a novel system of organotypically cultured rat hippocampal slices on a planar 60-microelectrode array (MEA). T...

Dae-Sik Lee et al. 667 ABSTRACT⎯This letter presents a smart integrated microfluidic device which can be applied to actively immobilize proteins on demand. The active component in the device is a temperature-controllable microelectrode array with a smart polymer film, poly(N-isopropylacrylamide) (PNIPAAm) which can be thermally switched between hydrophilic and hydrophobic states. It is integrat...

| In this paper, we give a brief review of pattern classification algorithms based on discriminant analysis. We then apply these algorithms to classify movement direction based on multivariate local field potentials recorded from a microelectrode array in the primary motor cortex of a monkey performing a reaching task. We obtain prediction accuracies between 55% and 90% using different methods ...

This article reports the use of commercial, flexible printed circuit technology for the fabrication of low-cost microelectrode arrays (MEAs) for recording extracellular electrical signals from cardiomyocyte cultures. A 36-electrode array has been designed and manufactured using standard, two-layer, polyimide-based flexible circuit technology, with electrode diameters of 75 and 100 m. Copper str...

This work presents a multiparametric system capable of characterizing and classifying white wines according to the grape variety and geographical origin. Besides, it quantifies specific parameters of interest for quality control in wine. The system, known as a hybrid electronic tongue, consists of an array of electrochemical microsensors-six ISFET based sensors, a conductivity sensor, a redox p...

Multilayering microelectrode techniques have been developed to construct large-area travelling-wave dielectrophoresis (TWD) separators. Novel electrode designs have enabled arrays with up to 25 000 electrodes to be constructed. The separation capacity of a 1000 electrode (20 mm) array has been demonstrated by separating components of whole blood. The development of sophisticated bio-particle se...

ABSTRACT This paper presents the in situ quantitative monitoring of the anticancer drug doxorubicin (DOX) efflux from the drug resistant lung cancer cells NCI-H69AR by using a microelectrode array integrated compact electrochemical system. This approach achieves a sensitive, quantitative, non invasive and real-time efflux assay that can help address drug resistance, a major therapeutic stumblin...

We report on the identification and tracking of the electrical activity of processes of single neurons. With a newly designed complementary metal-oxide-semiconductor (CMOS) based integrated highdensity microelectrode array (HD-MEA) [1,2], we were able to simultaneously use more than 1000 electrodes and low-noise readout channels to monitor electrophysiological signals of many individual branche...

We introduce a synchrony map that translates the fine temporal organization of multi-unit responses in the visual cortex into an easily interpreted spatial display. We test the synchrony map on microelectrode array recordings in Area 17 of anesthetized and paralyzed cats. We first examine the synchrony map using averaged data and probability calculations to demonstrate orientation-dependent cha...