Introduction Most commercially-available dry powder inhaler (DPI) formulations utilize a carrier-based formulation concept. Utilizing a mixing process, micronized active pharmaceutical ingredient (API) particles are attached to the surface of larger excipient particles. Multiple studies list excipients such as mannitol, glucose monohydrate, trehalose, dextrose, maltose, sorbitol and maltitol fo...

In this first of two articles, we discuss some issues surrounding the dissolution rate enhancement of poorly-soluble active ingredients micronized into nano-particles using several supercritical fluid particle design processes including rapid expansion of supercritical solutions (RESS), supercritical anti-solvent (SAS) and particles from gas-saturated solutions/suspensions (PGSS). Experimental ...

Oat (Avena sativa L.) by-products are valuable sources of many bioactive compounds and minerals. This paper aimed to study the possibility using micronized oat husk (hull) as a partial replacement for wheat flour (at levels 5, 10, 15, 20%) in shortbread production. The physicochemical sensory properties control enriched cookies were studied. incorporation into increased fiber ash content, decre...