BACKGROUND Diabetes mellitus is associated with microvascular and macrovascular diseases, potentially manifested as endothelial dysfunction. In adults with type 2 diabetes the haptoglobin genotype 1-1 has been shown to have a protective role in inhibiting the development of complications. Although complications from type 1 diabetes are infrequent during childhood, endothelial dysfunction, which...

diabetic mellitus (dm) is a major risk factor of morbidity, mortality and economic cost to society. diabetic patients are at risk of having microvascular or macrovascular disorders of diabetes. postoperative anemia have wide spectrum of some early complications that require more care in hospitalization stays. therefore, this study was designed to evaluate effect of preoperative anemia on short-...

D iabetes induces a high degree of morbidity and significant reduction of life expectancy in affected subjects. Microvascular complications include retinopathy, nephropathy, and neuropathy, which frequently are underlying factors of major morbidity and disability associated with diabetes. However, macrovascular complications, and mainly cardiovascular disease, are still the leading causes of de...

Exogenous insulin administration and oral anti-diabetic drugs are the primary means of treating diabetes. However, tight glycaemic control, with its inherent risk of hypoglycaemia, is required to prevent the microvascular and macrovascular complications of the disease. While islet or pancreas transplantations offer a longer-term cure, their widespread application is not possible, primarily beca...

An intact endothelial cell barrier maintains normal gas exchange in the lung, and inflammatory conditions result in barrier disruption that produces life-threatening hypoxemia. Activation of store-operated Ca2+ (SOC) entry increases the capillary filtration coefficient ( K f,c) in the isolated rat lung; however, activation of SOC entry does not promote permeability in cultured rat pulmonary mic...

OBJECTIVE The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study continues to address knowledge gaps in our understanding of type 1 diabetes and the effects of intensive therapy on its long-term complications. RESEARCH DESIGN AND METHODS During the DCCT (1982-1993), a controlled clinical trial of 1,441 subjects with type 1 diabete...

The primary aim of type 2 diabetes mellitus treatment is to achieve and maintain good glycemic control, and to minimize the mortality and risk of microvascular and macrovascular complications. Current algorithms for medical management of type 2 diabetes mellitus recommend a combination of lifestyle intervention and metformin as initial therapy and ‘gold standard’ treatment. Numerous studies sug...

Type 2 diabetes mellitus (T2DM) has become a worldwide health problem, and the rate of it is growing greatly in the People's Republic of China every year. T2DM could cause macrovascular and microvascular complications that lead to an increase in arterial wall thickness, endothelial dysfunction, calcification, and - finally - to an increase in arterial stiffness and arterial dysfunction. Aloglip...