Background and Aim: In the present study, the cerebral surface landmarks in human fresh autopsy specimens were investigated. Methods and Materials/Patients: Totally, 37 fresh adult autopsy human brain specimens from the Rasht Forensic Medicine Center were enrolled. Four specimens were excluded because of some traumatic injuries to cerebral cortex. Demographic information of all cases was obt...

This paper reports atmospheric profiles of N2O retrieved from Metop/IASI with the Software for Retrieval IASI Data (SOFRID) 2008–2018 period and their validation FTIR data 12 stations Network Detection Atmospheric Composition Changes (NDACC). SOFRID retrievals performed in 2160–2218 cm−1 spectral window provide 3 independent pieces information about vertical profile N2O. The versus comparisons ...

BACKGROUND AND PURPOSE Little is known about the structural alterations within gray matter (GM) in middle-aged subjects with white matter hyperintense (WMH) lesions. Here, we aimed to examine the anatomical changes within the GM and their relationship to WMH lesion loads in middle-aged subjects. PARTICIPANTS AND METHODS Twenty-three middle-aged subjects with WMH lesions (WMH group) and 23 dem...

Acute schistosomiasis is characterized by pro-inflammatory responses against tissueor organ-trapped parasite eggs along with granuloma formation. Here, we describe studies in Cx3cr1 mice and demonstrate the role of Cx3cr1 in the pathoetiology of granuloma formation during acute schistosomiasis. Mice deficient in Cx3cr1 were protected from granuloma formation and hepatic injury induced by Schist...

The human platelet-specific alloantigens HPA-2a and HPA-2b (= Kob and Koa) together constitute a biallelic antigen system. The HPA-2 antigens have not, to date, been located on a particular platelet membrane molecule. Here, we describe the localization of these antigens on platelet glycoprotein (GP) Ib alpha. Platelets from two patients with the Bernard-Soulier syndrome (BSS) were HPA-2(a-,b-) ...

Diabetic vasculopathy is intensified by macrophage inflammation caused by advanced glycation end products (AGEs). Heparanase (HPA) is a unique endoglycosidase, which cleaves heparan sulfate proteoglycans (HSPGs) including syndecan-1 (Syn-1) to further stimulate macrophage cell migration and inflammation. The present study was planned to evaluated the role of C-domain (if any) of HPA in AGE infl...

Evidence of aberrant hypothalamic-pituitary-adrenocortical (HPA) activity in many psychiatric disorders, although not universal, has sparked long-standing interest in HPA hormones as biomarkers of disease or treatment response. HPA activity may be chronically elevated in melancholic depression, panic disorder, obsessive-compulsive disorder, and schizophrenia. The HPA axis may be more reactive t...

Brain imaging studies have identified a left-lateralized network of regions that are engaged when monolinguals read. However, for individuals who are native speakers of two languages, it is unclear whether this pattern of activity is maintained across both languages or if it deviates according to language-specific properties. We used functional magnetic resonance imaging to investigate single-w...

Stratospheric and middle mesospheric ozone profiles have been continually measured by the GROMOS (GROundbased Millimeter-wave Ozone Spectrometer) microwave radiometer since 1994 above Bern, Switzerland (46.95◦N, 7.44◦E, 577 m). GROMOS is part of the Network for the Detection of Atmospheric Composition Change (NDACC). A new version for the retrieval of ozone profiles of the ozone profile retriev...

The efflux transporter P-glycoprotein, expressed at high levels at the blood-brain barrier, exerts a profound effect on the disposition of various therapeutic compounds in the brain. A rapid and efficient modulation of this efflux transporter could enhance the distribution of its substrates and thereby improve central nervous system pharmacotherapies. This study explored the impact of the intra...