In the developing CNS, commissural axons are initially attracted to the midline, but after crossing they acquire sensitivity to midline repellent cues which prevent re-crossing. Recent studies have shed new light on the mechanism by which commissural axons change their sensitivity to guidance cues after crossing the midline.

The bipotential Ganglion Mother Cells, or GMCs, in the Drosophila CNS asymmetrically divide to generate two distinct post-mitotic neurons. Here, we show that the midline repellent Slit (Sli), via its receptor Roundabout (Robo), promotes the terminal asymmetric division of GMCs. In GMC-1 of the RP2/sib lineage, Slit promotes asymmetric division by down regulating two POU proteins, Nubbin and Mit...

abstract we had two cases of female complicated anorectal and genital malformations which underwent total mobilization of all structures of perinea to midline. case1: a 6 month old female with skin covered bladder, pubic diastasis, ectopic anus, vagina, and urethra to the right side of median cleft and lipoma on the left side. closure of pubic diastasis with iliac osteotomy and double barrel si...

the purpose of the current study was to determine whether infiltration of bupivacaine in the incision site of midline laparotomy reduces postoperative pain and opioid consumption. fifty-six, 30-60 year-old patients who were undergoing midline laparotomy were enrolled in the present study. the patients were randomly assigned into two groups of control (group c, n = 28) or bupivacaine (group b, n...

Ultrasound as a technique in neurological diagnosis was introduced by Leksell in 1955, and is now gaining acceptance as a useful screening test for intracranial tumours and haematomas. The technique uses a pulsed ultrasonic beam transmitted from a probe (transducer) applied to the temporal region of the skull. The ultrasound is then reflected from a 'midline structure' within the cranium. Space...