Identifying immunocompromised women who are at risk of developing cervical cancer remains a challenge for clinicians. In an effort to identify the role HIV in carcinogenesis, this study evaluated levels normally downregulated oncomirs (miR-21, miR-146a, miR-155, miR-182, and miR-200c) upregulated tumor suppressors (miR-let-7b, miR-125b, miR-143, miR-145, p53 expression) associated with serum li...

One of the mechanisms for development autoimmune diseases is changes in epigenetic regulation, root causes which have not yet been established. At same time, data on role transposons as sources long noncoding ribonucleic acids (RNA) and microRNAs involved immune pathology accumulated. In evolution, transposable elements become basis emergence V(D)J recombination regulation HLA genes. Pathologic...

Breast cancer is a leading cause of related death among women worldwide and it complex disease characterized by its heterogeneity. The heterogenous characteristic the breast responsible for aggressiveness treatment resistance. stem cells (BCSCs) are population with increased propensity proliferation, differentiation, migration, invasion mammosphere formation resistance to treatment. They have a...

In this paper we consider estimation of the derivative of a density based on wavelets methods using randomly right censored data. We extend the results regarding the asymptotic convergence rates due to Prakasa Rao (1996) and Chaubey et al. (2008) under random censorship model. Our treatment is facilitated by results of Stute (1995) and Li (2003) that enable us in demonstrating that the same con...

Objective(s): MicroRNAs (miRNAs) are considered as powerful, post-transcriptional regulators of gene expression in hepatocellular carcinoma cells (HCC). However, the function of miR-92a is still unclear in HCC. Materials and Methods: Expression of miR-92a in human HCC cell lines was evaluated using qRT-PCR. MTT assay and transwell assay were used to examine the function of miR-92a in HepG2 and ...

Helicobacter pylori infection is considered as an excellent model of chronic inflammation-induced tumor development. Our project focuses on gastric MALT lymphoma (GML) related to H. pylori infection and mediated by the chronic inflammatory process initiated by the infection. Recently, microRNAs (miRNAs) have emerged as a new class of gene regulators, which play key roles in inflammation and car...

Therapeutic inhibition of the miR-34 family (miR-34a,-b,-c), or miR-34a alone, have emerged as promising strategies for the treatment of cardiac pathology. However, before advancing these approaches further for potential entry into the clinic, a more comprehensive assessment of the therapeutic potential of inhibiting miR-34a is required for two key reasons. First, miR-34a has ∼40% fewer predict...

Citation: Yang H, Wang H, Shu Y and Li X (2018) miR-103 Promotes Neurite Outgrowth and Suppresses Cells Apoptosis by Targeting Prostaglandin-Endoperoxide Synthase 2 in Cellular Models of Alzheimer’s Disease. Front. Cell. Neurosci. 12:91. doi: 10.3389/fncel.2018.00091 miR-103 has been reported to be decreased in brain of transgenic mouse model of Alzheimer’s disease (AD) and in cerebrospinal flu...

objective: mir-302-367 is a cluster of polycistronic micrornas that are exclusively expressed in embryonic stem (es) cells. the mir-302-367 promoter is functional during embryonic development but is turned off in later stages. motivated by the cancer stem cell hypothesis, we explored the potential expression of mir-302 in brain tumor cell lines. materials and methods: in the present experimenta...