The objective of this work was to investigate in experiments on laboratory rats the possibility reducing cardiotoxicity anticancer drug Mitomycin C by mixing it with Mesogel before injection and using Mexicor® as a cardioprotective agent. Materials methods. To carry out study, 70 male Wistar were used. body weight animals at beginning experimental study ranged from 180 220 grams. Intraperitonea...

purpose: to evaluate the corneal endothelial cell density and polymegathism one year after laser assisted keratomileusis using mitomycin c. methods: one hundred and three eyes from 52 patients who underwent laser assisted sub-epithelial keratomileusis using mitomycin c 0.02% for 30 seconds entered this study. corneal endothelial cells were evaluated using specular microscopy before and one year...

Physico-chemical properties, molecular interactions and thermodynamic stability of human and bovine serum albumins in complexes with mitomycin C were investigated. The pH and temperature influence on serum albumins properties and the binding mechanism of mitomycin C to these proteins have been monitored by spectrometry and spectrofluorimetry methods.

The antitumor antibiotic mitomycin C is shown to form a covalent complex with calf thymus DNA under anaerobic conditions in the presence of either NADPH cytochrome c reductase/NADPH, xanthine oxidase/NADH, or the chemical reducing system H2/PtO2. Digestion of the complex with DNase I/snake venom diesterase/alkaline phosphatase yields a single mitomycin deoxyguanosine adduct as the major DNA alk...

BACKGROUND The purpose of the present study is to quantify the in vitro antiproliferative and cytotoxic effects of mitomycin-C on human keratocytes for their potential to modulate corneal stromal wound healing. METHODS Cultured human keratocytes were exposed to various concentrations of mitomycin-C for periods of 5 minutes and 1 hour. Keratocyte proliferation and viability were assessed by ph...

We have observed the selective toxicity of mitomycin C toward hypoxic as compared to aerobic cells in vitro for three established cell lines (Chinese hamster ovary, Chinese hamster V-79, and human HeLa) and for cells from the transplantable KHT murine tumor. The magnitude of the selective toxicity was cell line dependent. We have studied the in vivo effects of mitomycin C against aerobic and hy...