Ambient particulate matter varies in composition and toxicity; therefore, some heterogeneity in risk per unit mass can be anticipated. In this issue of the Journal (Am J Epidemiol 2007;166:880–888), Dominici et al. explore temporal and spatial effect modification of particulate matter potency with the goal of gaining insights about how differences in the mixture may affect toxicity of the parti...

The toxicity of perfluorinated surfactants perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorobutane sulfonate (PFBS) and PF-656 as well as the sulfosuccinate surfactant docusate sodium has been examined using two bioluminescence inhibition assays based on the marine bacterium Vibrio fischeri and the self-luminescent cyanobacterial recombinant strain Anabaena CPB4337....

Metal-based nanoparticles (NPs) are the most widely used engineered nanomaterials. The individual toxicities of metal-based NPs have been plentifully studied. However, the mixture toxicity of multiple NP systems (n ≥ 3) remains much less understood. Herein, the toxicity of titanium dioxide (TiO₂) nanoparticles (NPs), silicon dioxide (SiO₂) NPs and zirconium dioxide (ZrO₂) NPs to unicellular fre...

Ambient particulate matter varies in composition and toxicity; therefore, some heterogeneity in risk per unit mass can be anticipated. In this issue of the Journal (Am J Epidemiol 2007;166:880-888), Dominici et al. explore temporal and spatial effect modification of particulate matter potency with the goal of gaining insights about how differences in the mixture may affect toxicity of the parti...

Waste accumulation is reported to be one of the serious environmental problems. Organic wastes such as organic fraction of municipal solid waste (OFMSW) or sewage sludge (SS) can be treated using aerobic microbial decomposition called composting. It is important to know when composts obtained in co-treatment processes turns to be safe but not toxic for the environment. In this study, we estimat...

stachys lavandulifolia is used as the herbal tea and its wide and potent medical effects have been reported for the extract in animal studies. this study aimed to find the safety profile of the extract to find the appropriate doses for further human studies. the aerial parts of the plant were air-dried and the hydroalcoholic extract was obtained and concentrated by percolation method with 140 m...

Sanitary landfill leachate (SLL) is a mixture of highly toxic and recalcitrant pollutants that threatens the water quality Yucatán Peninsula karst aquifer, one most extensive aquifers on planet. To reduce adverse environmental impacts this wastewater, triple-stage Fenton process (FP) was applied in an old SLL. Removal efficiencies were evaluated terms physicochemical variables, metal(oid)s conc...

Among proposed uses for microarrays in environmental toxiciology is the identification of key contributors to toxicity within a mixture. However, it remains uncertain whether the transcriptomic profiles resulting from exposure to a mixture have patterns of altered gene expression that contain identifiable contributions from each toxicant component. We exposed isogenic rainbow trout Onchorynchus...

Acivicin is an investigational amino acid antitumor antibiotic currently being evaluated in Phase II clinical trials. In humans acivicin causes reversible, dose-limiting central nervous system (CNS) effects including somnolence, ataxia, personality changes, and hallucinations. We have observed and reported previously that acivicin-treated cats exhibit symptoms (ataxia, sedation, somnolence) res...

Background & Aims of the Study: The present research aims to use sediment quality indices in the assessment of toxicity and ecological risk factors of heavy metals Pb, Cu and Zn in Anzali, Meighan, Shadegan and Hashilan wetlands. Material & Methods: Given the environmental conditions, surface sediments in 71 diverse stations were sampled in three replications. Having preparation and subject...