Tulane virus (TV) is a newly reported calicivirus that was isolated from stool samples of captive rhesus macaques from the Tulane National Primate Research Center (TNPRC). The virus has been cultivated successfully in LLC-MK2 rhesus monkey kidney cells. Its complete genomic sequence suggests that TV represents a new genus and is evolutionarily more closely related to Norovirus than to any other...

Stress granules (SGs) are dynamic cytoplasmic foci at which stalled translation initiation complexes accumulate in cells subjected to environmental stress. SG-associated proteins such as TIA-1, TIAR and HuR bind to AU-rich element (ARE)-containing mRNAs and control their translation and stability. Here we show that tristetraprolin (TTP), an ARE-binding protein that destabilizes ARE-mRNAs, is re...

The DNA damage response depends on the concerted activity of protein serine/threonine kinases and modular phosphoserine/threonine-binding domains to relay the damage signal and recruit repair proteins. The PIKK family of protein kinases, which includes ATM/ATR/DNA-PK, preferentially phosphorylate Ser-Gln sites, while their basophilic downstream effecter kinases, Chk1/Chk2/MK2 preferentially pho...

Microwave irradiation of 2-halobenzonitriles and methyl thioglycolate in the presence of triethylamine in DMSO at 130 °C provides rapid access to 3-aminobenzo[b]thiophenes in 58-96% yield. This transformation has been applied in the synthesis of the thieno[2,3-b]pyridine core motif of LIMK1 inhibitors, the benzo[4,5]thieno[3,2-e][1,4]diazepin-5(2H)-one scaffold of MK2 inhibitors and a benzo[4,5...

In order to increase the paired-domination number of a graph G, minimum edges that must be subdivided (where each edge in G can no more than once) is called subdivision sdγpr(G) G. It well known sdγpr(G+e) smaller or larger for some e∉E(G). this note, we show that, if an isolated-free different from mK2, then, every e∉E(G), sdγpr(G+e)≤sdγpr(G)+2Δ(G).

A study has been performed to measure the resistance of Pall Ultipor BB50 filters when exposed to humidified air for 48 h during artificial ventilation by an Engstrom Erica ventilator fitted with a Bennett Cascade Mk2 humidifier. A marked increase in resistance was demonstrated. A hypothesis is presented as to the aetiology of these findings together with details of minor modifications to the s...

To ensure the risk level associated with continuously increasing maritime traffic through particularly sensitive sea areas remains at acceptable level, a periodic assessment needs to be carried out by relevant authorities. As part of such assessment, allowing for proactive countermeasures mitigate risk, frequency accidents is estimated along geographical locations where are most likely happen. ...

Flood irrigation is often applied in the arid regions of Northwest China to facilitate leaching salts accumulated soil during cotton growth previous season. This will, turn, affect temporal and spatial patterns salinity, thus germination. To reveal salinity two layers (0–20 cm 20–60 cm), so as determine optimal sowing timing, an electronic ground conductivity meter (EM38-MK2) was employed measu...