background: lymphocytes of fanconi anemia (fa) show an increased sensitivity to the alkylating agents such as mitomycin c (mmc), but their responses to gamma-irradiation is controversial. the extent of dna damage in leukocytes of fa patients following irradiation and mmc treatment was studied at cellular and single chromosome level. methods: dna damage induced by gamma-rays and mmc was measured...

purpose : although applying mitomycin c (mmc) during photorefractive keratectomy (prk) has shown to reduce postoperative corneal haze but there is considerable evidence of mmc toxicity in the literature and concerns exist regarding side effects and long-term complications. we conducted this study to compare the efficacy of mmc 0.02% and 0.01% in prevention of haze after prk. methods : 210 eyes ...

BACKGROUND To be successful, cost control efforts must target Medicaid Managed Care (MMC) beneficiaries likely to incur high costs. The critical question is how to identify potential high cost beneficiaries with simple, reproducible, transparent, auditable criteria. Our objective in this analysis was to evaluate whether the total burden of comorbidity, assessed by the Charlson comorbidity index...

BMY-25282, 7-N-(dimethylamino methylene)mitomycin C, is one of a novel series of amidino mitomycin derivatives. Some of these were discovered as intermediates in a synthetic program being conducted to find improved procedures for modifying the structure of mitomycin C (MMC). Markedly superior in vivo antitumor effects have been observed with BMY-25282 compared to MMC in initial tests against i....

PURPOSE The present study investigated the effect of mitomycin C (MMC) on cell viability, apoptosis, and transforming growth factor beta-induced protein (TGFBIp) expression in cultured normal corneal fibroblasts and heterozygote or homozygote granular corneal dystrophy type II (GCD II) corneal fibroblasts. METHODS Keratocytes were obtained from normal cornea or from heterozygote or homozygote...

BACKGROUND Recurrent TaT1 non-muscle-invasive bladder cancer (NMIBC) patients should be treated with immediate instillation of chemotherapy after transurethral resection of bladder tumour followed by instillation therapy. OBJECTIVE To present long-term results of a study exploring the effect of initial mitomycin C (MMC) instillations followed by two types of immunotherapy for patients with fr...

A review is presented on the enhancement of MMC (mitomycin C) efficiency by the vitamins C, E and b-carotene using E. coli bacteria (AB 1157) and leukemia cells (HL 60) as a model for experiments in vitro. New and previously published spectroscopic and kinetic data of transients obtained by pulse radiolysis of MMC and the above mentioned vitamins were also discussed. Based on all these results ...

Some environmental mutagenic agents cause genomic instability and increase susceptibility of DNA damage. One of them is mitomycin C which is connected to DNA as an alkylating factor and affects susceptible cells to reduction reactions. This drug is used in chemotherapy and treatment of tumors. Study of genomic instability in the presence of different concentrations of MMC can show susceptibilit...

The modular multilevel converter is improved topology for high-voltage, high-power applications since the cascaded sub modules can generate high-voltage waveforms with excellent harmonic performance at low switching frequencies. Many publications have been presented on the modulation and control of this converter type, some of which are based on phase-shifted carrier modulation. This paper pres...

Introduction: Otorrhea and granulation tissue in Canal Wall Down mastoidectomy (CWD) is the common problem in cholesteatoma removal and leads to many discomfort for both the patient and the physician. The main objective in CWD is creating the dry cavity, so the topical antibiotic and acetic acid in variable saturations are used for this purpose. In this study we evaluate the effectiveness of to...