Cancer metastasis is tightly regulated by the interaction of tumor cells and host organ microenvironments. Matrix metalloproteinases (MMPs), produced by both tumor cells and host stromal cells, play a central role in tumor invasion and angiogenesis. We determined whether metastatic potential of lung cancer to multiple organs is dependent solely on the expression of MMPs by tumor cells, using tw...

In this paper we extend the classical min-max model predictive control framework to a class of uncertain discrete event systems that can be modeled using the operations maximization, minimization, addition and scalar multiplication, and that we call max-min-plus-scaling (MMPS) systems. Provided that the stage cost is an MMPS expression and considering only linear input constraints then the open...

Martix metalloproteinases (MMPs), one of the subgroups of the metzincins, are a large family of zinc-dependent endoproteases with multiple roles in extracellular matrix remodelling and modulation of signalling pathways. They are able to cleave all protein components of the extracellular matrix, as well as to activate or inactivate various signaling molecules, such as receptors, growth factors a...

The matrix metalloproteinase (MMP) family plays an important role in the degradation of extracellular matrix (ECM) in various physiological and pathological conditions. Accumulated evidence has suggested that MMPs contribute to cancer cell invasion of the surrounding normal tissues and metastasis through the cell-surface ECM degradation. Strong correlations have been reported between elevated M...

The family of human matrix metalloproteinases (MMPs) comprises several tightly regulated classes of proteases. These enzymes and their specific inhibitors play important roles in tumour progression and the metastatic process by facilitating extracellular matrix degradation. As scientific understanding of the MMPs has advanced, therapeutic strategies focusing on blocking these enzymes by matrix ...

Matrix metalloproteinase (MMP)-2 and MMP-9 are gelatinases that take part in several reproductive processes. The aim of this study was to measure levels MMP-2 fractionated stallion ejaculates, evaluate the association between these components semen quality, sperm longevity during cooled storage. Semen quality were assessed separately for sperm-rich fractions (HIGH), sperm-poor (LOW), whole ejac...

Background: Many studies have been conducted on the sika deer, an extinct species in Korea, to analyze physiological characteristics of restoration and reproductive characteristics. The mechanisms water deer especially function, morphological changes, ovarian characteristics, are unknown. Objective: We aimed study differences physiology determine difference function through analysis cell remode...