The relationship between expression of cell surface glycoproteins encoded by the major histocompatibility complex (MHC) and immunogenicity of a recently obtained spontaneous murine mammary adenocarcinoma (designated CBA.SP1) was examined. Immunogenic and nonimmunogenic variant clones were isolated from a subclone of the parent tumor after treatment with the mutagen N-methyl-N'-nitro-N-nitrosogu...

Sporadic microsatellite mutations are frequently observed in lung, bladder, and head and neck tumors with intact DNA mismatch repair. AAAG tetranucleotide repeats appear to be especially prone to the accumulation of these mutations. We hypothesized that occurrences of microsatellite mutations in these cancers may be linked to DNA damage caused by exposure to carcinogens in tobacco smoke. To tes...

Abstract Recent studies on osteosarcoma regimens have mainly focused modifying the combination of antineoplastic agents rather than enhancing therapeutic efficacy each component. Here, an albumin nanocluster (NC)‐assisted methotrexate (MTX), doxorubicin (DOX), and cisplatin (MAP) regimen with improved antitumor is presented. Human serum (HSA) decorated thiamine pyrophosphate (TPP) to increase a...

DNA repair-defective alleles of the mei-9, mei-41, mus-104 and mus-101 loci of Drosofihila melanogaster were introduced into stocks bearing the UZ and SZ marker sets. Males with the UZ marker set, z1 (zesle allele) and w + ( ' ~ ) (genetically unstable white allele presumably caused by a transposable element), or the SZ marker set, z ' and w + ~ (semistable white allele caused by partial duplic...