A companion manuscript revealed that deletion of the Pseudomonas aeruginosa (Pae) PA1006 gene caused pleiotropic defects in metabolism including a loss of all nitrate reductase activities, biofilm maturation, and virulence. Herein, several complementary approaches indicate that PA1006 protein serves as a persulfide-modified protein that is critical for molybdenum homeostasis in Pae. Mutation of...

This paper describes a pair of compact CW/FM airborne SAR systems for small UAV-based operation (wingspan of 3.5 m) for low-cost testing of innovative SAR concepts. Two different SAR instruments, using the C and X bands, have been developed in the context of the ARBRES project, each of them achieving a payload weight below 5 Kg and a volume of 13.5 dm3 (sensor and controller). Every system has ...

The recently advanced unsupervised learning approaches use the siamese-like framework to compare two "views" from same image for representations. Making views distinctive is a core guarantee that methods can learn meaningful information. However, such frameworks are sometimes fragile on overfitting if augmentations used generating not strong enough, causing over-confident issue training data. T...

Self-supervised contrastive learning offers a means of informative features from pool unlabeled data. In this paper, we investigate another useful approach. We propose an entirely coreset selection method. regard, learning, one several self-supervised methods, was recently proposed and has consistently delivered the highest performance. This prompted us to choose two leading methods for learnin...

Motion is a serious artifact in Cardiac nuclear imaging because the scanning operation takes a long time. Since reconstruction algorithms assume consistent or stationary data the quality of resulting image is affected by motion, sometimes significantly. Even after adoption of the gold standard MoCo(R) algorithm from Cedars-Sinai by most vendors, heart motion remains a significant challenge. Als...

C ompelling evidence supports the hypothesis that modern cells descended from organisms whose components were made entirely of RNA. Scientists who helped formulate this “RNA World” hypothesis for the evolution of life have identified many characteristics of modern cells that strongly suggest RNA once ruled the planet. For example, the existence of selfcleaving and self-splicing ribozymes that c...

BACKGROUND Molybdenum cofactor deficiency (MOCD) is a severe autosomal recessive neonatal metabolic disease that causes seizures and death or severe brain damage. Symptoms, signs and cerebral images can resemble those attributed to intrapartum hypoxia. In humans, molybdenum cofactor (MOCO) has been found to participate in four metabolic reactions: aldehyde dehydrogenase (or oxidase), xanthine o...

Background T2* measurement is widely used in the assessment of patients at risk for cardiac and hepatic iron overload (1,2). The conventional breath-hold, ECG-triggered, segmented, multi-echo gradient echo sequence (BH MGRE) used for myocardial T2* quantification (3) is very sensitive to respiratory motion and may not be feasible in patients who are unable to breath-hold. To overcome this limit...