background and objective: p53 is a suppressive gene that plays a key role in dna repair and apoptosis. the purpose of this study was to investigate the effect of p53 protein over-expression and some clinicopathological factors on the esophageal squamous cell carcinoma (scc) response to neoadjuvant chemoradiotherapy. patients and methods: in this retrospective cohort study, 44 patients with loca...

In the recent years, interstitial brachytherapy implantation has become the treatment of choice for early stage prostate cancer patients. Treatment of prostate cancer with radiation is traced back to 1909. Originally this treatment modality was very crude and could not gain much popularity till 1982. Advancements in radioactive source designs, introduction of new low energy radioactive sources,...

for the first time we have used eyelid skin expansion to facilitate reconstruction of selected patients with shortage of lid skin (e.g. for burn scar and after excision of tumors). this method allows for a controlled increase in skin, need for reconstruction, and offers many advantages over grafted skin transfered from a distance. color, texture, thinness, delicacy and adnexal structures are ae...

Abstract Quadruple and Quintuple Helix Innovation Systems aim to optimize the design operation of modern, democratic societies economies in a smart, sustainable, inclusive, resilient efficacious manner via cyber-physical ecosystems that align with Industry 5.0 Society precepts. In this context, Framework (which is part Quadruple/Quintuple or Q2IH) represents most comprehensive, meaningful valua...

the relationship between population structure and violent conflict is complex and heavily dependent on the behavior of other variables like governance, economic prospects, and urbanization. while addressing rapid population growth might be a necessary condition for peace, it is by no means sufficient. concomitant steps must also be taken to foster inclusivity, guarantee broader rights for all, ...