Development of efficient molecular medicines, including gene therapeutics, RNA therapeutics, and DNA vaccines, depends on efficient means of transfer of DNA or RNA into the cell. Potential problems, including toxicity and immunogenicity, surrounding viral methods of DNA delivery have necessitated the use of nonviral, synthetic carriers. To better design synthetic carriers, or transfection reage...

We examine a sequential mechanism which is a simple modification of the normal form mechanism introduced by Abreu and Matsushima (1992). We show that almost any social choice function can be virtually implemented via a finite sequential game of perfect information. The solution concept assumed is backwards induction. In particular, any social choice function that is virtually implementable via ...

Multisite covalent modification of proteins is omnipresent in eukaryotic cells. A well-known example is the mitogen-activated protein kinase (MAPK) cascade where, in each layer of the cascade, a protein is phosphorylated at two sites. It has long been known that the response of a MAPK pathway strongly depends on whether the enzymes that modify the protein act processively or distributively. A d...