Gastroesophageal cancer is a significant global problem that frequently presents at an incurable stage and has very poor survival with standard chemotherapy approaches. This review will examine the epidemiology and molecular biology of gastroesophageal cancer and will focus on the key deregulated signaling pathways that have been targeted in the clinic. A comprehensive overview of clinical data...

Gastric cancer is the fifth most frequently diagnosed cancer and the third leading cause of cancer mortality. In advanced gastric cancer patients, the treatment outcomes are dismal. With the development of the molecular targeted therapy, the prognosis in patients with advanced and unresectable gastric cancer are improved. This article reviewed the molecular targeted agents in clinical use, thei...

Targeted radionuclide therapy is one of the most intensively developing directions of nuclear medicine. Unlike conventional external beam therapy, the targeted radionuclide therapy causes less collateral damage to normal tissues and allows targeted drug delivery to a clinically diagnosed neoplastic malformations, as well as metastasized cells and cellular clusters, thus providing systemic thera...