During my academic years at the College of William and Mary, I have fifty published and peer-reviewed papers, among which fifteen are journal papers and thirty-five are conference papers. I have acquired three external research grants funded by the National Science Foundation, with one recent and two others from a while back. I have graduated three Ph.D. students, with the fourth passing the pr...

T HE use of monoamine oxidase (MAO) inhibitors in the treatment of hypertension has been limited until recently, mainly because the available compounds had a high incidence of accompanying side reactions.' However, the non-hydrazine MAO inhibitor, pargyline, appears to be an effective drug with a relatively low incidence of untoward effects. Clinical studies have substantiated that pargyline is...

Although no evidence has been reported linking infection by members of the Coxsackie Group B viruses with the aetiology of endemic diarrhoea, the results of several virological investigations into sporadic outbreaks of this disease have suggested a causal relation between infection by the Coxsackie Group B viruses and the accompanying diarrhoea syndrome (Heggie, Schultz, Gutekunst, Rosenbaum, a...

In the present study, we evaluated the influence of intraperitoneal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or 1-methyl-4-phenylpyridinium (MPP(+)) on the placenta. There was no increase in apoptotic cells in the placentas of C57BL/6 mice treated with 25.0 mg/kg MPTP or 17.1 mg/kg MPP(+), indicating that a single injection of the chemicals may induce very slight cy...

Previous papers in this series have described the crystallization and preliminary characterization of beef plasma monoamine oxidase (1) as well as the fact that cupric copper is one of the prosthetic groups of this enzyme (2). In the present paper, studies related to the second prosthetic groups of this enzyme are presented and the results discussed. A preliminary report has already been publis...

Cite this article: Clark SJ, Wang Q, Mao-Draayer Y (2016) Switching from Natalizumab to Fingolimod: Case Report and Review of Literature. J Immunol Clin Res 3(1): 1030. *Corresponding author Yang Mao-Draayer, Department of Neurology, University of Michigan Medical School, 4015 A. Alfred Taubman Biomedical Sciences Research Building, 109 Zina Pitcher Place, Ann Arbor, Michigan 48109-2200, Tel: 7...

Eugene Gregoryanz, Alexander F. Goncharov, Russell J. Hemley, Ho-kwang Mao, Maddury Somayazulu, and Guoyin Shen Geophysical Laboratory, Carnegie Institution of Washington, 5251 Broad Branch Road NW, Washington, D.C. 20015 HPCAT, Carnegie Institution of Washington, APS, 9700 South Cass Avenue, Argonne, Illinois 60439 GSECARS, University of Chicago, APS, 9700 South Cass Avenue, Argonne, Illinois ...

T HE use of monoamine oxidase (MAO) inhibitors in the treatment of hypertension has been limited until recently, mainly because the available compounds had a high incidence of accompanying side reactions.' However, the non-hydrazine MAO inhibitor, pargyline, appears to be an effective drug with a relatively low incidence of untoward effects. Clinical studies have substantiated that pargyline is...

OBJECTIVE The current study examined the efficacy and safety of rasagiline, a selective MAO-B inhibitor, for the treatment of persistent negative symptoms. METHODS Sixty people with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, schizophrenia or schizoaffective disorder, who met a priori criteria for persistent negative symptoms, were randomized to receive rasagiline, ...

Recent positron emission tomography imaging studies have demonstrated a significant decrease in both monoamine oxidase A and B (MAO-A and MAO-B) activities in the brains of smokers. Normal levels of activity are observed in former smokers, suggesting the presence of one or more compounds in tobacco smoke that may inhibit these enzymes. In this paper, we report the results of efforts to identify...