Characterizing the microstructural evolution of lipid aggregates and precipitates in lithogenic bile is pivotal for understanding the process of cholesterol crystallization, leading to cholesterol gallstone formation. We have studied cholesterol precipitation in bile models and in human bile samples by the combined use of lightand cryotransmission electron microscopy with density gradient separ...

The objective of this experiment is to formulate the tigecycline injection by lyophillization technique for better stability and for long term storage. Lactose monohydrate and lactose sprat dried were used with water for injection and hydrochloric acid into 5 ml tubular vials with pre and post purging nitrogen. The filled vials were loaded into lyophilizer and lyophilized them as per cycle. Dif...

In the title square-planar copper complex, [Cu(C(20)H(22)N(2)O(6))], the Cu-N and Cu-O bond lengths are significantly longer than those of its isostructural nickel analog. The title structure is related to that of the corresponding monohydrate. There are significant differences in the conformations of the two complexes. While the monohydrate is mainly planar, in the title compound there is a sl...

A sensitive, selective and stability indicating reverse phase method has been developed for the quantitative determination of potential impurities of Desvenlafaxine succinate monohydrate active pharmaceutical ingredient. Efficient chromatographic separation was achived on C8 stationary phase. Forced degradation study confirmed that the newly developed method was specific and selective to the de...

In the crystal structure of the title compound, {[Cd(C(2)Cl(3)O(2))(2)(C(12)H(10)N(2))(2)]·H(2)O}(n), the Cd(II) ion lies on a twofold rotation axis and 1,2-bis-(4-pyrid-yl)ethene ligands bridge symmetry-related Cd(II) ions, forming a two-dimensional structure. Two trichloro-acetate ligands complete the coordination around the Cd(II )ion, forming a distorted octa-hedral environment. In the crys...

The title structure, {[Ba(0.71)Sr(1.29)(C(4)HO(4))(4)(H(2)O)(10)]·H(2)O}(n), is built from dimers of edge-sharing monocapped square anti-prisms [(Ba/Sr)O(3)(H(2)O)(6)], in which barium and strontium are statistically disordered [ratio 0.353 (8):0.647 (8)] on the same crystallographic site. Such dimers are connected via bidentate hydrogen squarate groups [HC(4)O(4)](-), leading to chains that pr...

In the crystal structure of the title compound, C(4)H(12)N(2) (2+)·C(6)H(6)O(7) (2-)·H(2)O, the cations, anions and water mol-ecules are linked by inter-molecular N-H⋯O, O-H⋯O and weak C-H⋯O hydrogen bonds into a three-dimensional network. An intra-molecular O-H⋯O inter-action occurs in the dianion.