Morphologic changes in cortex and white matter of the cerebral frontal lobes in vascular dementia were studied. The signs of leykoaraiosis in white matter were revealed. Obvious signs of neurodegeneration expressed in loss of neurons, which is considered to be the attribute of aging process and may be one of significant etiologic factors of vascular dementia, had not been identified.

Three morphologic patterns of interaction between bacteria and enterocytes have been observed in colonic biopsy specimens from AIDS patients with chronic diarrhea in the United States. The DNA encoding virulence factors and the HEp-2 cell adherence patterns of Escherichia coli strains isolated from the stools of eight symptomatic AIDS patients were compared with those of five control strains wi...

Rats were administered 24 mg/kg of paraquat intraperitoneally. One, two, three, six and seven days after this injection, the rats were evaluated by several toxicologic, biochemical, and morphologic criteria. These included determinations of weight loss, visible lung hemorrhage, pulmonary edema, in vitro protein and collagen biosynthesis rates of lung tissue, and staining properties of lung sect...

I NTENSE INTEREST EXPRESSED BY CLINIcians, physiologists, and pathologists in pulmonary emphysema has stimulated the need for establishing some criteria for the normal anatomy and subsequent pathologic change. Regardless of the conflict in the theories of etiology, we must be cognizant of certain changes which take place in the pulmonary parenchyma. The fine relationships between structure, fun...

● Context.—Glioblastoma (GBM), the most common primary intracranial malignancy, is a morphologically diverse neoplasm with dismal prognosis despite multimodality therapy. Only 3 distinct morphologic variants of GBM are currently recognized by the current World Health Organization classification scheme, including GBM, giant cell GBM, and gliosarcoma. Additional variants, some of which have signi...

• Vol 7 • December 2005 768 A key question for understanding chronic inflammatory and autoimmune diseases is where the disease actually begins. Wegener’s granulomatosis is a potentially life-threatening chronic inflammatory disease of as yet unknown etiology, characterized by granuloma formation, vasculitis, and an autoimmune response to “Wegener’s autoantigen“ proteinase 3, a 29 kD neutrophila...