Motoneuron excitability and muscle spasms are regulated by 1 5-HT2B and 5-HT2C receptor activity. 2 3 Katherine C. Murray, Marilee J. Stephens, Edmund W. Ballou, Charles J. Heckman, 4 and David J. Bennett 5 Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada; Department of Physiology, 6 Northwestern University, Chicago, IL, USA. 7 8 9 Running Title: 5-HT2B receptors on mot...

Motoneuron survival in the embryonic spinal cord is influenced by the presence or absence of the developing limb bud. We have recently begun a reexamination of the relationship between limb absence and motoneuron survival in a nonsurgical limb deletion model, the limbless mutant chick embryo. As in surgically limb-deleted normal embryos, only 10% of the motoneurons that are initially produced i...

Introduction: Neurotrophins belong to growth factor family and their function is based on their receptors. They bind two types of receptors: p75 and tyrosine kinase. The motoneuron survival or death depends upon the neurotrophic factors. Recent studies have demonstrated that axotomy in peripheral nerve induces apoptosis of motoneuron. Deprenyl or Selegiline is known as a drug with neuroprote...

The purpose of the article is to explore need and advantages using incoherent color holography lattice light-sheet (ICHLLS) provide multiwavelength quantitative monitoring 3D cellular dynamics in live tissue further understand complex functions cells compartments. We have explored use investigate colocalization fluorescent markers intact tissue. Neuronal structures an attractive target for ligh...

A conditioned patellar tendon reflex paradigm was used to study the contributions of crossed spinal and supraspinal inputs to the output of the alpha motoneuron pool in children with and without developmental coordination disorders. The basic patellar tendon reflex response was exaggerated in children with developmental coordination disorders. Crossed spinal and supraspinal influences on the ex...

Respiration requires the coordinated rhythmic contractions of diverse muscles to produce ventilatory movements adapted to organismal requirements. During fast locomotion, locomotory and respiratory movements are coordinated to reduce mechanical conflict between these functions. Using semi-isolated and isolated in vitro brain stem-spinal cord preparations from neonatal rats, we have characterize...

the purpose of this study was to investigate the validity of the modified ashworth scale (mas) by using both the conventional (hmax/mmax ratio) and the new indicators (hslp/mslp) of motoneuron excitability. this research was a correlational study on twenty post-stroke patients. main outcome measures were the mas and electrophysiologic assessments. the latter was performed using both conventiona...

Following nerve injury in neonatal rats, a large proportion of motoneurons die, possibly as a consequence of an increase in vulnerability to the excitotoxic effects of glutamate. Calcium-dependent glutamate excitotoxicity is thought to play a significant role not only in injury-induced motoneuron death, but also in motoneuron degeneration in diseases such as amyotrophic lateral sclerosis (ALS)....