Malignant tumors develop through multiple steps of initiation and progression, and tumor initiation is of singular importance in tumor prevention, diagnosis, and treatment. However, the molecular mechanism whereby a signaling network of interacting pathways restrains proliferation in normal cells and prevents tumor initiation is still poorly understood. Here, we have reported that the Hippo, Wn...

The developmental process is a highly complicated process for building multicellular organisms. JMCB has published several research works in recent collections on this topic (Wu, 2013, 2014). In the present issue, five more articles report new biological factors and cell signaling pathways that are discovered controlling the developmental process. These findings might provide new insights into ...

Long noncoding RNAs (lncRNAs) play an important role in the regulation of gene expression and are involved several pathological responses. However, many lncRNAs breast cancer have not been identified their levels functions remain unknown. In this study, lncRNA apoptosis-associated transcript bladder (AATBC) was found to be significantly highly expressed patients. vitro vivo experiments indicate...

BACKGROUND The Hippo signaling pathway plays fundamental roles in stem cell maintenance in a variety of tissues and has thus implications for stem cell biology. Key components of this recently discovered pathway have been shown to be associated with primordial follicle activation. However, whether the Hippo signaling pathway plays a role in the development of Ovarian Germline Stem Cells (OGSCs)...

Other names: DKFZp686K23225 HGNC (Hugo): RASSF6 Location: 4q13.3 Local order: Centromere-AFP-AFM-RASSF6-IL8Telomere. Note Brief overview : The RASSF family of tumour suppressor genes (TSG) encode Ras superfamily effector proteins that, amongst other functions, mediate some of the growth inhibitory functions of Ras proteins. Several members of this family are inactivated by promoter DNA hypermet...

First discovered in Drosophila, the Hippo signaling pathway is a conserved regulator of organ size. Central to this pathway is a kinase cascade leading from the tumor suppressor Hippo (Mst1 and Mst2 in mammals) to the oncoprotein Yki (YAP and TAZ in mammals), a transcriptional coactivator of target genes involved in cell proliferation and survival. Here, I review recent progress in elucidating ...

Logarithmic signatures for finite groups are the essential constituent of public key cryptosystems MST1 and MST3. Especially they form the main component of the private key of MST3. Constructing new classes of logarithmic signatures having features that do not share with the well-known class of transversal or fused transversal logarithmic signatures, has become a vital issue regarding the use o...