The mu-opioid receptor (mu-OR), like most G-protein-coupled receptors, is rapidly internalized after agonist binding. Although opioid peptides induce internalization in vivo, there are no studies that demonstrate mu-OR internalization in response to natural stimuli. In this study, we used laser-scanning microscopy to demonstrate that estrogen treatment induces the translocation of mu-OR immunor...

We study harmonic analysis on cocommutative KPC-hyper-groups‎, which is a generalization of DJS-hypergroups‎, ‎introduced by Kalyuzhnyi‎, ‎Podkolzin and Chapovsky‎. ‎We prove that there is a relationship between‎ ‎the associated measures $mu$ and $gamma mu$‎, ‎where $mu$ is‎ ‎a Radon measure on KPC-hypergroup $Q$ and $gamma$ is a character on $Q$.

Evolution of mutation rate controlled by a neutral modifier is studied for a locus with two alleles under temporally fluctuating selection pressure. A general formula is derived to calculate the evolutionarily stable mutation rate mu(ess) in an infinitely large haploid population, and following results are obtained. (I) For any fluctuation, periodic or random: (1) if the recombination rate r pe...

Muscle fiber-type grouping (‘clumping’) in cross-sections of patient muscle biopsies and the electrophysiological recordings of enlarged motor unit action potentials (MUAPs) are almost universally interpreted as peripheral nerve damage with subsequent reinnervation of denervated muscle fibers [1, 2]. Other electromyographic potentials, including nascent potentials, are indicators of early muscl...

The Mutator system of transposable elements is characterized by a family of transposons called Mu transposons that share common termini and are actively transposing in Robertson's Mutator (Mu) lines of maize. Mu lines lose transposition activity during propagation by either outcrossing or inbreeding. This loss of transposition activity, which can occur at non-Mendelian frequencies, is in the fo...

The opioid receptor preference for dermorphin and several dimerized structural analogues was investigated using rat brain synaptosomes and correlated with the potencies of intracerebroventricularly administered dimeric dermorphin peptides to inhibit gastric acid secretion. The carboxyl terminus of dermorphin or amino-terminal dermorphin analogues was bridged by dihydrazide or (poly)ethylenediam...

the edge szeged index is a new molecular structure descriptor equal to the sum of products mu(e)mv(e) over all edges e = uv of the molecular graph g, where mu(e) is the number of edges which its distance to vertex u is smaller than the distance to vertex v, and nv(e) is defined analogously. in this paper, the edge szeged index of one-pentagonal carbon nanocone cnc5[n] is computed for the first ...