The Anti-Mullerian hormone (AMH), which is produced by fetal Sertoli cells, is responsible for regression of Mullerian ducts, the anlagen for uterus and Fallopian tubes, during male sex differentiation. Ovarian granulosa cells also secrete AMH from late in fetal life. The patterns of expression of AMH and its type II receptor in the post-natal ovary indicate that AMH may play an important role ...

Mullerian inhibiting substance (MIS) is the gonadal hormone that causes regression of the Mullerian ducts, the anlagen of the female internal reproductive structures, during male embryogenesis. MIS is a member of the large transforming growth factor-beta (TGF beta) multigene family of glycoproteins that are involved in the regulation of growth and differentiation. The proteins in this gene fami...

Deficiency of vitamin D3 has become common in both developed and developing countries. Vitamin D receptors are found on the granulosa cells ovarian tissue its deficiency plays a role dysfunction. Anti Mullerian Hormone (AMH) is generated small growing follicles ovaries by cells. Serum AMH one marker for reserve. We reviewed current literature present clinical practice. There relationship betwee...

BACKGROUND Mc Indoe vaginoplasty is one of the mostly performed surgical interventions in Mullerian agenesis. CASE PRESENTATIONS We present our experience on the use of a new designed vaginal stent that was coated with silicone in two mullerian agenesis cases who had Mc Indoe vaginoplasty. Both full thickness and splitt thickness skin graft were used with the stent. No graft loss or hyperthro...

Toremifene is an anti-estrogen which has been shown to be effective in the treatment of breast cancer, and is thought to be a less uterotrophic agent than tamoxifen. The risk assessment concerning endometrial cancer has been inconclusive because of its rare use up to the mid-1990s. We report a case of an adenosarcoma, which is a very rare type of uterine malignancy, after toremifene treatment f...

Malignant mixed Mullerian tumors of the cervix are very rare tumors, constituting only 0.005% of all cervical malignancies. It usually presents with abnormal vaginal bleeding in post-menopausal women. The tumor has high rates of metastasis, so careful management including surgery, chemotherapy and/or radiotherapy is done for these patients. Here, we present a case of a 47 year old woman who pre...

BACKGROUND Leiomyoma with secondary changes arising from Mullerian remnant may mimic ovarian tumor in women with Mayer-Rockitansky-Kuster-Hauser (MRKH) syndrome in patients with pelvic mass and urologic abnormalities. CASE DETAIL The patient was a 40 years old known case of MRKH, presented with lower abdominal pain and swelling for over one year. On physical examination, large pelvic mass (ab...

Background: Herlyn-Werner-Wunderlich (HWW) syndrome is a rare variant of Mullerian duct anomalies. The characteristic triad this includes didelphys uterus, obstructed hemivagina, and ipsilateral renal agenesis, recently known as Obstructed Hemivagina Ipsilateral Renal Anomaly (OHVIRA) syndrome. most common presentation abdominal pelvic pain, dysmenorrhea, mass secondary to hematocolpos, hematos...

MAIN FINDINGS A typical male looking adolescent with a legal female gender assignment presented with haematuria. Investigations led to the diagnosis of Persistent Mullerian Duct Syndrome. The condition is indeed a rare entity that needs a multidisciplinar team management. Case hypothesis: A case of Persistent Mullerian Duct Syndrome undiagnosed at birth because karyotyping was defaulted, thus r...