We describe an approach to building a hybrid multi-scale model, using a Petri net model for the top layer, and object-oriented models at the lower layers, with a rigorous definition of how the layers compose. We apply this approach to building a model of prostate cell division and differentiation, with each model layer describing the processes at a suitable level of abstraction. This provides a...

For a Virtual Learning Environment a Digital Pedagogy is required, otherwise learning will be the same as usual with the only difference being, that reading and writing will be on the computer, and therefore the opportunity to use the Computer Science and Technology to empower the student’s learning is lost. The Digital Pedagogy needs to be Multi-Referential, which means that different knowledg...

Recently there has been renewed interest in alternative modelling approaches, driven by recognised deficiencies in the traditional four step model. One stream of development has come through improved modelling of individual and household travel scheduling and joint decision making, under the umbrella of tour-based and activity-based modelling. Another stream of development has been improved app...

the existing works considering the flow-based discount factor in the hub and spoke problems, assume that increasing the amount of flow passing through each edge of network continuously decreases the unit flow transportation cost. although a higher volume of flow allows for using wider links and consequently cheaper transportation, but the unit of flow enjoys more discounts, quite like replacing...

Multi-agent systems exhibit highly dynamic behaviour within dynamic environments. Modelling of individual agents within such systems demands considering both evolving data structures and the control over their internal changing states. In addition, modelling of the overall system implies modelling of the agents’ configuration, including their ability to exchange messages as well as the ability ...

In this thesis, hierarchical graphs are investigated from two different angles – as a general modelling principle for (geo)spatial networks and as a practical means to enhance navigation in buildings. The topics addressed are of interest from a multi-disciplinary point of view, ranging from Computer Science in general over Artificial Intelligence and Computational Geometry in particular to othe...

Systems biology has developed considerably in the past decade combining the different disciplines of mathematical modelling, computational simulation and biological experimentation facilitating the quantitative analysis of biological systems. This is often severely hampered by the lack of time-resolved data which ultimately leads to problems in validating any models created. To address the inhe...

Software engineering describes a system at different levels of abstraction. Agent-oriented software engineering introduces a new level, called the agent level, to allow the software architect modelling a system in terms of interacting agents. This level of abstraction is not yet supported by an accepted diagrammatic notation even if a number of proposals are available. This paper shows how UML ...