BACKGROUND Colchicine is used in the treatment and prophylaxis of gout. It possesses a narrow therapeutic window, frequently resulting in dose-limiting gastrointestinal side-effects such as diarrhoea and emesis. As colchicine is a cellular anti-mitotic agent, the most serious effects include myelosuppression, myoneuropathy and multiple organ failure. This occurs with intentional overdose or wit...

The clinical features of corona virus disease 2019 (COVID-19) are variable, but the majority patients experience mild flu-like symptoms. cases severe include complications such as progressive pneumonia, acute kidney injury, multi-organ failure, and even death. This paper explores association between COVID-19 its effect on multiple organ systems how subsequent treatment this can itself lead to m...

Langerhans cell histiocytosis (LCH) is a clonal neoplasm that shows diverse clinical manifestations and courses of disease progression. The etiology and pathophysiology of LCH remain uncertain. We describe the clinical course of a 23-year-old Japanese woman with multi-system LCH, who showed rapid progression after steroid reduction and developed multi-organ failure. Liver biopsy showed LCH infi...

LCH: Langerhans cell histiocytosis INTRODUCTION Langerhans cell histiocytosis (LCH) identifies a spectrum of disorders that are classified according to the organs involved (singleor multi-organ disease) and the presence or absence of organ failure. Patients younger than 2 years with a multisystem disease have a significantly higher mortality rate than older children. Nail involvement in LCH is ...

Acute myeloid leukemia (AML) is one of the most frequent myeloid malignancies. In patients with the disease, death often occurs due to complications of marrow failure, such as sepsis or significant hemorrhage. Rarely, undiagnosed and rapid evolving cases may present with fatal multi-organ failure. The authors report a case of sudden death in a 67-year-old woman who had been in apparent good hea...

background there is evidence that early enteral nutrition can improve clinical outcomes in patients hospitalized in the intensive care unit. objectives the purpose of this study was to evaluate the effect of early enteral nutrition on clinical outcomes in medical patients admitted to the intensive care unit. materials and methods this prospective study was performed on 94 patients admitted to t...

Malignant hypertension (MH) is a state which can rapidly progress to multi-organ failure. It develop in the course of both primary and secondary type hypertension. In our study, we present case 36-year-old man diagnosed with renal failure MH complicated retinopathy. As nature condition was suspected extensive diagnostics has been conducted. spite excluding plenty pathologies, underlying cause r...

Abstract Cardiac disease and the death rates due to coronary heart failure cardiomyopathy are increasing. Thoracic transplantation is now a widely accepted therapeutic option for end-stage cardiac failure. The survival rate after organ crucial. Survival prediction hot area of research. use conventional statistical techniques computationally expensive does not provide reliable solutions. Artific...

We read with great interest the article ‘A case of emphysematous hepatitis with spontaneous pneumoperitoneum in a patient with hilar cholangiocarcinoma’ by Jung Ho Kim et al. The authors described fatal case of emphysematous hepatitis caused by C. perfringens , but did not mention the hemolysis or disseminated intravascular coagulopathy (DIC) during hospital course. Laboratory data on admission...