Binding to plasma proteins is a key parameter in evaluating candidate compounds during the lead optimization and early ADME phases of the drug development process. Biacore’s surface plasmon resonance (SPR) technology is ideally suited for the analysis of multiple aspects of drug-plasma protein interactions. BiacoreS51 was used to analyze a panel of low molecular weight drug compounds for bindin...

This study investigated aggressive, withdrawn, and prosocial behavior in physically abused (N = 21), nonabused-neglected (N = 26), and nonabused-nonneglected (N = 21) children aged 5 to 8 years. Multiple assessment techniques were used, specifically the Human Figure and Kinetic Group Drawings, children's verbal stories, and teacher ratings on the Pittsburgh Adjustment Survey Scales. All measure...

We examine how local direction signals are combined to compute the focus of radial motion (FRM) in random dot patterns and examine how this process changes across the visual field. Equivalent noise analysis showed that a loss in FRM accuracy was largely attributable to an increase in local motion detector noise with little or no change in efficiency across the visual field. The minimum separati...

Endemic melioidosis is caused by genetically diverse Burkholderia pseudomallei strains. However, clonal outbreaks (multiple cases caused by 1 strain) have occurred, such as from contaminated potable water. B. pseudomallei is designated a group B bioterrorism agent, which necessitates rapidly recognizing point-source outbreaks. Pulsed-field gel electrophoresis (PFGE) and multilocus sequence typi...

Enteropathogenic Escherichia coli (EPEC) is a leading cause of diarrhea among infants in developing countries. A total of 38 EPEC isolates, obtained from diarrhea patients of Hospital Miri, Sarawak, were investigated through plasmid profile, antibiotic resistance and randomly amplified polymorphic DNA (RAPD) analysis. From the 8 types of antibiotics used, all isolates were 100% resistant to fur...

Binding to plasma proteins is a key parameter in evaluating candidate compounds during the lead optimization and early ADME phases of the drug development process. Surface plasmon resonance (SPR) technology is ideally suited for the analysis of multiple aspects of drug-plasma protein interactions. Here we describe how a BiacoreTM SPR based system was used to analyze a panel of low molecular wei...

Objective. To evaluate the validity of the Activities-specific Balance Confidence scale (ABC) in people with multiple sclerosis (PwMS). Design. A multicentre, cross-sectional study. Setting. Six rural and urban Swedish sites, including specialized units at hospitals and primary care centers. Participants. A sample of 84 PwMS with subjective gait and balance impairment but still able to walk 100...

This study investigated the classification of multiple-objective, timber and non-timber motivated family forest landowner groups in the three southeastern states of Alabama, Georgia and South Carolina. Using non-parametric discriminatory analysis procedures we found that the bio-physical, socio-economic and demographic variables that best discriminated the three landowner groups. Analysis resul...

This study investigated the combined capability of thallium-201 (Tl)-SPECT and fluorine-18-fluoro-deoxy-glucose (FDG)-PET for differential diagnosis of posterior fossa brain tumors using multiple discriminant analysis.This retrospective study was conducted under approval of the institutional review board. In the hospital information system, 27 patients with posterior fossa intra-axial tumor bet...