multiple sclerosis (ms) is an autoimmune disease of the central nervous system (cns) which causes demyelination of the nerve fibers. the etiology of this disease is not well understood but it is believed that t helpers play a central role in ms. numerous findings support the view that th17 cells play an essential role in pathogenesis of ms and il-17 secreting t (th17) cells have a role in infla...

when pooled immunoglobulin g (igg) from patients with multiple sclerosis (ms) was used to probe a human fetal spinal cord λgt 11 cdna library, the igg was found to bind to a predicted epitope of human mitochondrial nd4 sequence. to investigate the involvement of the nd4 as an autoantigen in ms, we determined the presence of specific antibody in the serum of ms patients and serum samples of some...

conclusions components of social support, totally account for 19% of resiliency variance value of patient; the components of social support, family, friends, and other people’s support at only had lower contribution in predicting resiliency. support of this group of people to increase their resiliency seems necessary. results there was a significant association between social support and resili...

background: multiple sclerosis (ms) is a chronic disease characterized by degradation of the central nervous system myelin which may impair the balance of patients. core stability exercises have been the focus of attention for repairing the stability of some patients.   objectives: to assess the effect of core stability exercise on the balance of patients with multiple sclerosis. materials and ...

Eight patients are described who presented with hemiparesis which involved the face in seven. Six of the eight subsequently developed clinically definite multiple sclerosis and in the remaining two patients multiple sclerosis was the likely diagnosis. Magnetic resonance imaging gave useful information about the site of the lesions responsible for the presenting syndrome and provided additional ...

In this study, we describe prominent perivenular spaces as a sign that is seen on high-resolution (512 x 512) transverse T2-weighted MR images in patients with multiple sclerosis. The observed widening of perivenular space is depicted as a stringlike hyperintensity projecting radially and aligned with multiple sclerosis lesions (usually small), following the course and configuration of deep ven...

The clinical and pathological features of multiple sclerosis were fully described, in France and subsequently in England, during the latter half of the XIXth century but clinical descriptions, personal accounts and depictions of the disease had appeared at various times over the previous 50 years. Jean Cruveilhier is usually credited with having first illustrated the lesions of multiple scleros...

BACKGROUND The cerebellum is an important site for cortical demyelination in multiple sclerosis, but the functional significance of this finding is not fully understood. OBJECTIVE To evaluate the clinical and cognitive impact of cerebellar grey-matter pathology in multiple sclerosis patients. METHODS Forty-two relapsing-remitting multiple sclerosis patients and 30 controls underwent clinica...

Recent evidence supports a role for glutamate receptors in the pathophysiology of multiple sclerosis. In the present study, we have focused specifically on the expression of metabotropic glutamate receptors (mGluRs) in multiple sclerosis brain tissue. The expression of group I (mGluR1alpha and mGluR5) and group II (mGluR2/3) mGluRs was studied using immunohistochemistry in tissue from 12 multip...

Recent studies have identified numerous pathologies in the cranial domes of pachycephalosaurid dinosaurs. These utilized CT images to identify secondary woven bone and sclerosis associated with pathologies. features were critical for diagnosing post-traumatic osteomyelitis, which supported head-butting behaviour hypothesis. However, conventional image resolution may not be sufficient or sclerot...