Background: In the recently published meta-analysis of multiple sclerosis genome-wide association studies De Jager et al. identified three single nucleotide polymorphisms associated to MS: rs17824933 (CD6), rs1800693 (TNFRSF1A) and rs17445836 (61.5 kb from IRF8). To refine our understanding of these associations we sought to replicate these findings in a large more extensive independent sample ...

The purpose of this scientometric study is to analyze the multiple sclerosis research in Science Citation Index-Expanded from 1992 to 2019 in order to determine the top features, trends, and topics. Articles related to multiple sclerosis in the section of title, abstract, keywords, and KeyWords Plus were retrieved from the Science Citation Index-Expanded and analyzed based on various indicators...

results two major themes were extracted from the analysis of the transcripts: “comprehensive caring commitment” and “patients’ medication grudge”. conclusions according to the findings, the nurses are in a unique position to care for people with ms; therefore they should be ready to provide high-quality patient care in ms patients. patients must be encouraged to study about their condition and ...

objective: the main purpose of this study was to investigate the effectiveness of lazarus multimodal psychotherapy (mmt) on perceived stress in individuals with multiple sclerosis (ms). methods: through a quasi-experimental design, forty patients in qazvin city in iran were selected by convenient sampling and then divided into two groups: experimental and control groups. after group assignment,...

conclusions this study showed that mbsr training can reduce mean depression, anxiety and stress scores in patients with ms. these findings suggest that mbsr is useful for psychological problems such as depression, anxiety and stress in patients with ms. patients and methods this randomized controlled clinical trial was performed in 2013 in ahvaz ms society. forty eight patients were selected by...

background: recent studies have demonstrated controversial results and somewhat increased frequency of multiple  sclerosis  (ms). we reevaluated  the  files of  ms patients  from qom province of iran in order to investigate the epidemiology of the disease. methods:   demographic   and  clinical records  of  592  ms patients  were reviewed, which included; age, sex, date  of birth, marital and o...

multiple sclerosis (ms) is a chronic auto-immune disease. most therapeutic strategies for treatment of this disease direct immune modulation and control of inflammatory processes. first-line therapeutic agents showed moderate efficacy and frequent side-effects with moderate efficacy in trials. their parental administration and limited long-term adherence restrict their efficacy compared with se...

background: neuromyelitis optica (nmo) is an uncommon neuro- inflammatory syndrome that has shown to be distinct from multiple sclerosis (ms) and associated with the autoantibody marker nmo-immunoglobulin g (igg). there are still only a few studies regarding the epidemiology of nmo in iran. in the present study, we tried to describe the epidemiology of nmo in khuzestan as one of the densely pop...

background: the aim of this preliminary study was to assess the safety and efficacy of high-dose oral vitamin d3 supplementation during pregnancy in women with multiple sclerosis (ms) in isfahan, iran. methods: in a single center open-label randomized, controlled clinical phase i/ii pilot study, 15 pregnant women with confirmed ms with low serum 25-hydroxyvitamin d (25(oh)d) levels were randoml...

background: available evidence shows that tetracycline family has cellular and molecular mechanisms to protect neurons and oligodendrocytes by modulating matrix metalloproteinases. we tried to compare the effectiveness of intramuscular and subcutaneous interferon beta-1a (inf-β1a) in combination with oral doxycycline among patient with relapsing remitting multiple sclerosis (rrms) and secondary...