Smooth muscle cell proliferation around small pulmonary vessels is essential to the pathogenesis of pulmonary hypertension. Here we describe a molecular mechanism and animal model for this vascular pathology. Rodents engineered to express angiopoietin 1 (Ang-1) constitutively in the lung develop severe pulmonary hypertension. These animals manifest diffuse medial thickening in small pulmonary v...

1. Large-scale mutagenic screens of the zebrafish genome have identified a number of different classes of mutations that disrupt skeletal muscle formation. Of particular interest and relevance to human health is a class of recessive lethal mutations in which muscle differentiation occurs normally, but is followed by tissue-specific degeneration reminiscent of human muscular dystrophies. 2. We h...

Dear Editor, We are submitting the revised manuscript entitled "Proteasome Inhibition Alleviates Prolonged Moderate Compression-induced Muscle Pathology" as an original research paper to BMC Musculoskeletal Disorders. In this study, we demonstrated the pathologic role of muscle ubiquitin proteasome in an experimental model of deep pressure ulcer. We have revised the manuscript according to the ...

BACKGROUND It is well established that prolonged, exhaustive endurance exercise is capable of inducing skeletal muscle damage and temporary impairment of muscle function. Although skeletal muscle has a remarkable capacity for repair and adaptation, this may be limited, ultimately resulting in an accumulation of chronic skeletal muscle pathology. Case studies have alluded to an association betwe...

Myonuclear apoptosis is an early event in the pathology of dystrophin-deficient muscular dystrophy in the mdx mouse. However, events that initiate apoptosis in muscular dystrophy are unknown, and whether elimination of apoptosis can ameliorate subsequent muscle wasting remains a major question. We have tested the hypothesis that cytotoxic T-lymphocytes initiate myonuclear apoptosis in dystrophi...

Rhabdomyosarcoma is highly aggressive malignant form of mesenchymal tumor arising from skeletal muscle cells rhabdomyoblast, that have failed to fully differenciate. It most commonly seen in the children before 12 year age. Primary spinal rhabdomyosarcoma very rare. A 2 old girl presented with mass over right upper back and inability move lower limb. Patient underwent dorsal laminectomy excisio...

A murine monoclonal antibody, F7, which selectively shows type I fibres in human skeletal muscle is reported. The antibody reacts with frozen sections and with formalin fixed wax embedded material. It should prove useful in the retrospective and prospective study of muscle pathology.

Smoking is the most important risk factor for the development of chronic obstructive pulmonary disease (COPD). Patients with COPD commonly suffer from skeletal muscle dysfunction, and it has been suggested that cigarette smoke exposure contributes to the development of skeletal muscle dysfunction even before overt pulmonary pathology. This review summarizes the evidence that muscles of nonsympt...