Bioactuators In article 2300151 by Robert K. Katzschmann and co-workers, a perfusable, biohybrid design enables the extrusion-based bioprinting of centimeter-scale skeletal muscle tissue that is cointegrated with synthetic anchors for mechanical stimulation crossed longitudinal channels passive liquid perfusion, which supports cell viability all over volume allows drug delivery distribution tes...

0430 Table LA Emptying fraction CMR Maximal LAVICMR LGE <17.5% >17.5% p <44 ml/m >44 ml/m p – + p Mitral E/A ratio 2.98±1.82 0.89±0.28 <0.001 1.51±1.4 2.22±1.8 0.2 1.35±1.3 2.43±1.9 0.055 DT TTE (ms) 158±45 217±56 <0.001 190±65 183±53 0.7 219±51 145 ±39 <0.001 Lateral E/e’ 16.9±6.8 12.1±6.4 <0.04 14±7 14.8±7 0.8 13.6±7.4 15.7±6.4 0.4 GLS –10.1±3.1 –17.3±3.7 <0.001 –14.2±5.3 –12.7±4.6 0.4 –16.5±...

Insulin and glucose delivery (muscle perfusion) can modulate insulin-mediated glucose uptake. This study was undertaken to determine 1) to what extent insulin sensitivity modulates the effect of perfusion on glucose uptake and 2) whether this effect is achieved via capillary recruitment. We measured glucose disposal rates (GDRs) and leg muscle glucose uptake (LGU) in subjects exhibiting a wide ...

BACKGROUND Experimental data demonstrate the persistence of a transmural vasodilator reserve in the face of depressed resting myocardial perfusion. The present study was designed to determine whether resting myocardial hypoperfusion indicates exhausted coronary reserve (CR). METHODS AND RESULTS Fifteen patients with stable angina, isolated left anterior descending coronary artery (LAD) stenos...

BACKGROUND In patients with stable coronary artery disease (CAD), decisions regarding revascularisation are primarily driven by the severity and extent of coronary luminal stenoses as determined by invasive coronary angiography. More recently, revascularisation decisions based on invasive fractional flow reserve (FFR) have shown improved event free survival. Cardiovascular magnetic resonance (C...

AIMS Patients with type 2 diabetes mellitus (T2DM) are known to have impaired resting myocardial energetics and impaired myocardial perfusion reserve, even in the absence of obstructive epicardial coronary artery disease (CAD). Whether or not the pre-existing energetic deficit is exacerbated by exercise, and whether the impaired myocardial perfusion causes deoxygenation and further energetic de...

We review the evolving findings from studies that examine the relationship between the structural and functional properties of skeletal muscle's vasculature and muscle metabolism. Unique aspects of the organization of the muscle microvasculature are highlighted. We discuss the role of vasomotion at the microscopic level and of flowmotion at the tissue level as modulators of perfusion distributi...